Original scientific paper
Prognostic significance of CA 15-3 tumor marker in breast cancer patients
Ana Valić
; Belupo, pharmaceutical company, Zagreb, Croatia
Ivan Milas
orcid.org/0000-0002-2083-1085
; University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Ljiljana Mayer
; University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Mia Šetić
; Catholic University of Croatia, Zagreb, Croatia
Valentina Matijević
; Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Mladen Stanec
; University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Abstract
The research objectives was to establish pre-operative values of the tumor marker CA 15-3 in serum and to establish onnection between serum level of the tumor marker CA 15-3 in patients with breast cancer with other prognostic factors for breast cancer (age, tumor size, lymph node status, histological grading, hormone receptor status). In this work, a retrospective study in 100 breast cancer patients who started their medical treatment in year 2007. on Department of Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice Clinical Hospital Center, has been made.
The concentration of tumor marker CA 15-3 was measured in serum by immunochemical method. When breast cancer was diagnosed, 11 patients had elevated tumor marker CA 15-3, while 89 patients had CA 15-3 within the normal range (values ≤28 kUI/L were considered within the reference range and values >28 kUI/L were considered elevated). Patients who developed metastases had signifi cantly higher values of pre-operative tumor marker CA 15-3 and that patients died from the same disease (mean, CA 15-3=30.67 kUI/L) . High levels of CA 15-3 had patients with positive lymph nodes (status N3, mean CA 15-3=52,78). Results from this research shown that correlation between pre-operativne value tumor marker CA 15-3 with age, ER expression, HER2 status and histologic grade were not found.
Elevated value of tumor marker CA 15-3 is at the time of diagnosis unfavorable prognostic factor, connected with other unfavorable prognostic factors. Justifi cation of this study was confi rmed by the value of preoperative tumor marker CA 15-3 in breast cancer patients and after determining its connection with other prognostic factors CA 15-3 indicates that is safer to extract subgroup of breast cancer patients in which metastases can be expected. As such, CA 15-3 can early focus on access to treatment by aggressive protocol.
Keywords
breast cancer; CA 15-3; prognostic signifi cance
Hrčak ID:
184428
URI
Publication date:
3.7.2017.
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