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Review article

https://doi.org/10.26332/seemedj.v1i1.21

Pharmacogenomics: Sex Differences and Application in Pediatrics

Ivana Bozic ; Department of Pharmacology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia
Tea Omanovic ; Department of Pharmacology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia
Lucija Kuna ; Department of Integrative Medicine, Faculty of Medicine, J. J. Strossmayer University of Osijek, Croatia
Tomislav Kizivat ; Clinical Hospital Center Osijek, Osijek, Croatia
Robert Smolic ; Department of Pharmacology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia; Clinical Hospital Center Osijek, Osijek, Croatia
Aleksandar Vcev ; Department of Pharmacology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia; Clinical Hospital Center Osijek, Osijek, Croatia
Martina Smolic ; Department of Pharmacology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia; Department of Integrative Medicine, Faculty of Medicine, J. J. Strossmayer University of Osijek, Croatia


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Abstract

Pharmacogenomics is a promising field which increasingly influences medicine and biomedical research in many areas. The aim of this article is to review recent advancements in the understanding of genetic polymorphisms and their influence on interindividual variability in drug response. Also, the main variabilities in drug response according to sex differences will be discussed. The translation of pharmacogenomics into the clinical routine as well as the challenges of achieving the goal of personalized medicine are also discussed. The role of pharmacogenetic tests in pediatrics has not been well defined yet, but it is clear that those tests could help in resolving some issues regarding the administration of drugs to children. At the conclusion, the foremost ethical, social and regulatory issues regarding the translation of pharmacogenomics into clinical practice and future perspectives in the field will be discussed.

Keywords

pharmacogenomics, medicine, clinical, pediatrics

Hrčak ID:

186756

URI

https://hrcak.srce.hr/186756

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