Original scientific paper

https://doi.org/10.1515/acph-2017-0037

Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury

JOO-IL KIM ; Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Korea; Central Research Institute, Daewon Pharmaceutical Company, 520 Cheonho-daero, Gwangjin-gu, Seoul, Republic of Kor
SANG-WOOK PARK ; Central Research Institute, Daewon Pharmaceutical Company, 520 Cheonho-daero, Gwangjin-gu, Seoul, Republic of Korea; Interdisciplinary Program in Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, 1, Gwanak-ro
JHONG-JAE LIM ; Central Research Institute, Daewon Pharmaceutical Company, 520 Cheonho-daero, Gwangjin-gu, Seoul, Republic of Korea
SE-IL SOHN ; Central Research Institute, Daewon Pharmaceutical Company, 520 Cheonho-daero, Gwangjin-gu, Seoul, Republic of Korea
JI-SUN SHIN ; Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Korea
SANG CHEOL PARK ; Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Korea; Department of Oriental Pharmaceutical Sciences, College of Pharmacy, Kyung Hee University, 26, Kyungheeda
YOUNG PYO JANG ; Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Korea; Department of Oriental Pharmaceutical Sciences, College of Pharmacy, Kyung Hee University, 26, Kyungheeda
EUN KYOUNG CHUNG ; Department of Pharmacy, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Korea
HONG-WOO LEE ; Central Research Institute, Daewon Pharmaceutical Company, 520 Cheonho-daero, Gwangjin-gu, Seoul, Republic of Korea
KYUNG-TAE LEE ; Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Korea; Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro,

Abstract

In this study, we investigated the gastroprotective effect of an isopropanol extract from the aerial parts of Artemisia princeps (IPAP) and developed a gastroretentive floating tablet of IPAP (IPAP-FR) for maximized local gastroprotective effects. Pre-treatment with IPAP ameliorated the gastric mucosal hemorrhagic lesions in ethanol/HCl- or indomethacin-treated rats. IPAP decreased mucosal hemorrhage of gastric ulcers induced by ethanol or indomethacin plus pyloric ligation in rats. The optimized floating tablet, IPAP-FR, floated on medium surface with more sustained eupatilin release compared to the non-floating control tablet. X-ray photographs in beagle dogs showed that IPAP-FR was retained for >2 h in the stomach. In the ethanol-induced gastric ulcer rat model, the gastric hemorrhagic lesion was improved more substantially with IPAP-FR compared to the non-floating control tablet. Based on these data, our data suggest that IPAP-FR has an improved therapeutic potential for the treatment of gastric ulcer.

Keywords

Artemisia princeps Pamp.; antiulcer; eupatilin; floating drug delivery system; X-ray photographs

Hrčak ID:

186844

URI

https://hrcak.srce.hr/186844

Publication date:

31.12.2017.

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