Psychiatria Danubina, Vol. 29 No. 4, 2017.
Short communication, Note
https://doi.org/10.24869/psyd.2017.497
OCCURRENCE OF POST-INJECTION DELIRIUM/SEDATION SYNDROME AFTER APPLICATION OF OLANZAPINE LONG-ACTING INJECTION DURING ONE YEAR PERIOD
Suzana Uzun
; University Psychiatric Hospital Vrapče, Zagreb, Croatia; University Josip Juraj Strossmayer Osijek, School of Medicine, Osijek, Croatia
Oliver Kozumplik
; University Psychiatric Hospital Vrapče, Zagreb, Croatia; University Josip Juraj Strossmayer Osijek, School of Medicine, Osijek, Croatia
Ivan Ćelić
; University Psychiatric Hospital Vrapče, Zagreb, Croatia
Nela Pivac
; Ruđer Bošković Institute, Division of Molecular Medicine, Laboratory for Molecular Neuropsychiatry, Zagreb, Croatia
Ninoslav Mimica
; University Psychiatric Hospital Vrapče, Zagreb, Croatia; School of Medicine, University of Zagreb, 10000 Zagreb, Croatia
Abstract
Introduction: The aim was to report the occurrence of after application of olanzapine long-acting injection (OLAI) in patients with schizophrenia during one year period.
Subjects and methods: During one year period, OLAI was applied to 30 patients with schizophrenia (18 men, 12 women) who were non-adherent to previous treatment with oral olanzapine. Patients were 20-58 years of age (39 years old on average), diagnosed with SCID based on DSM-IV-TR criteria. Patients received OLAI in dosage between 210-405 mg (287±62 (mean ± SD)) every 2-4 weeks.
Results: Out of 30 patients that received OLAI, 29 patients improved significantly without side-effects, and one patient developed post-injection delirium/sedation syndrome (PDSS). The patient's somatic condition stabilized and treatment with OLAI was discontinued due to the PDSS.
Conclusion: The occurrence of PDSS is not common and when it occurs, in our experience, it was reversible.
Keywords
olanzapine; patients; post-injection delirium/sedation syndrome; schizophrenia; treatment
Hrčak ID:
190611
URI
Publication date:
4.12.2017.
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