Original scientific paper
https://doi.org/10.22514/SV132.112017.16
The influence of dexmedetomidine on opioid consumption in radical prostatectomy
ALENKA SPINDLER-VESEL
orcid.org/0000-0002-6490-8451
; Department of Anaesthesiology and Surgical Intensive Therapy, University Medical Centre Ljubljana,Ljubljana, Slovenia
KSENIJA OGRIČ
NEVA POŽAR-LUKANOVIĆ
MATEJ JENKO
MAJA ŠOŠTARIČ
Abstract
Objective. Multimodal analgesia and analgesics
with different modes of action can
reduce perioperative opioid demand and
their undesirable side effects.
In our study we presumed that patients
anesthetised with additional perioperative
dexmedetomidine infusion, during radical
prostatectomy, would need less opioids
during and after surgery compared to the
control group.
Materials and methods. 40 patients, 18-80
years of age, ASA class 1-3 (American Society
of Anesthesiologists), scheduled for
radical prostatectomy, were included in
the study. Patients were randomly divided
into two groups (20 pts in each group). In
both groups, fentanyl in repeated boluses
was used as an analgesic; in the studied
group, an additional infusion of dexmedetomidine
(0.3 μg/kg/h) was started with
intravenous line insertion and continued
until the beginning of wound closure. Analgesic
consumption during the operation,
in the post-anaesthesia care unit, in the Intensive
Care Unit on the day of the operation
and on the first postoperative day was
recorded.
Results. The patients with perioperative
dexmedetomidine infusion were slightly
younger (p=0.007), also the duration of
their surgery was shorter (p =0.05). Differences
in opioid consumption between the
groups were not found. Also, pain assessment,
by visual analogue scale (VAS) after
12, 18, 24, 30, 36 and 42 hours, was not statistically
different between groups.
Conclusion. In our study, perioperative
dexmadetomidine did not reduce periand
postoperative opioid consumption.
Also, undesirable dexmedetomidine side
effects, such as bradycardia and hypotension,
were not observed.
Keywords
dexmedetomidine; radical prostatectomy
Hrčak ID:
190624
URI
Publication date:
12.12.2017.
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