Original scientific paper

https://doi.org/10.2478/acph-2018-0011

Hydroxyapatite-ciprofloxacin delivery system: Synthesis, characterisation and antibacterial activity

MARIA-VIORICA CIOCILTEU ; University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Craiova (Dolj), Romania
ANDREEA GABRIELA MOCANU ; University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Craiova (Dolj), Romania
ADRIANA MOCANU ; University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Craiova (Dolj), Romania
CATALIN DUCU ; CS I, Global Research S.R.L., Piteşti, Romania
OANA ELENA NICOLAESCU ; University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Craiova (Dolj), Romania
VALENTIN COSTEL MANDA ; University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Craiova (Dolj), Romania
ADINA TURCU-STIOLICA ; University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Craiova (Dolj), Romania
CLAUDIU NICOLICESCU ; University of Craiova, Faculty of Mechanics, Department of IMST, 220037, Drobeta Turnu Severin (Mehedinti), Romania
RAZVAN MELINTE ; University of Medicine and Pharmacy of Craiova, Faculty of Medicine, Craiova (Dolj), Romania
MARIA BALASOIU ; University of Medicine and Pharmacy of Craiova, Faculty of Medicine, Craiova (Dolj), Romania
OCTAVIAN CROITORU ; University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Craiova (Dolj), Romania
JOHNY NEAMTU ; University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Craiova (Dolj), Romania

Abstract

The main objective of this study was to synthesize hydroxyapatite-ciprofloxacin composites using a chemical precipitation method and to evaluate the properties and in vitro release profile of the drug from the hydroxyapatite-ciprofloxacin composites. Composite characterization was achieved by FT-IR, XRD and DLS. Ciprofloxacin determination was accomplished by HPLC, resulting in good incorporation efficiency of the drug (18.13 %). The in vitro release study (Higuchi model C = K t1/2 and Ritger-Peppas model, C = K t0.6) showed a diffusion-controlled mechanism. The antibacterial activity showed that the bacterial growth inhibition zones were approximately equal for the synthesis composites and for the mechanical mixture on the Staphylococcus aureus germ.
The use of hydroxyapatite, which is a biocompatible, bioactive and osteoconductive material, with ciprofloxacin, which has good antibacterial activity in this composite, makes it suitable for the development of bone grafts. Furthermore, the synthesis process allows a slow local release of the drug.

Keywords

hydroxiapatite-ciprofloxacin composites; wet precipitation synthesis; in vitro release profile; antibacterial activity

Hrčak ID:

193557

URI

https://hrcak.srce.hr/193557

Publication date:

30.6.2018.

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