Original scientific paper

Complex Formation Between the Antiviral Nucleoside Ribavirin (1-·B-D-Ribofuranosyl-1,2,4-Triazole-3-Carboxamide) and Bivalent Metal Ions: 1H and 13C NMR Studies, and Comparison with Inosine

Jože Kobe ; Boris Kidric Institute of Chemistry, Ljubljana, Yugoslavia
Zorica Crnjak Orel ; Boris Kidric Institute of Chemistry, Ljubljana, Yugoslavia
Jurkica Kidrič ; Boris Kidric Institute of Chemistry, Ljubljana, Yugoslavia

Abstract

The interactions O'f metal chlorides (MeClz) of group !La
(Me = Mg, Ca, Sr, Ba) and group !lb (Me = Zn, Cd, Hg) with
ribavi.rin, a potent broad spectrum antiviral nucleoside, and with
.Us structural analogue inosine were studied in DMSO-ds using
1H and 130 NMR methods. Proton limiting shift analysis was
made and 1H and 130 spin lattice relaxation times oif ribavirin
as a function o:f metal ion concentrations were determined.
The nature of the interactions was determined on the basis of
these data. The composition 01f comple1xes was determined using
J0 and Me2+-inosine complexoo in equilibrium were evaluated
either by concentration dependence or by a variaible temperature
method.

Keywords

Hrčak ID:

194180

URI

https://hrcak.srce.hr/194180

Publication date:

15.2.1984.

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