Acta clinica Croatica, Vol. 56. No. 4., 2017.
Original scientific paper
https://doi.org/10.20471/acc.2017.56.04.02
Clinical Significance of VEGF-A and Microvessel Density in Diffuse Large B-Cell Lymphoma and Low-Grade Follicular Lymphoma
Labinot Shahini
; Institute of Pathology, Faculty of Medicine, University of Prishtina, Prishtina, Kosovo
Slavko Gašparov
; Department of Pathology and Cytology, Merkur University Hospital, School of Medicine, University of Zagreb, Zagreb, Croatia
Gordana Petruševska
; Institute of Pathology, Faculty of Medicine, Cyril and Methodius University of Skopje, Skopje, Macedonia
Suzana Manxhuka Kerliu
; Institute of Pathology, Faculty of Medicine, University of Prishtina, Prishtina, Kosovo
Fahredin Veselaj
; Department of Urology, University Clinical Centre of Kosovo, Prishtina, Kosovo
Fisnik Kurshumliu
; Institute of Pathology, Faculty of Medicine, University of Prishtina, Prishtina, Kosovo
Floren Kavaja
; Department of Surgery, University Clinical Centre of Kosovo, Prishtina, Kosovo
Abstract
Angiogenesis is essential for the development, growth and progression of tumors. Although vascular endothelial growth factor (VEGF) is a well-known proangiogenic factor, its impact on lymphoma has not yet been fully clarified. The aim of this study was to evaluate VEGF-A expression and microvessel density (MVD) in aggressive lymphoma such as diffuse large B-cell lymphoma (DLBCL), in indolent lymphomas such as low-grade follicular lymphoma (FL), and in lymph node reactive follicular hyperplasia (FH). In 80 prospective and retrospective cases (30 DLBCL, 30 FL and 20 FH), CD31 was analyzed by immunohistochemical staining assessing density of blood vessels, as well as the total number of CD31 positive endothelial cells. The results were compared with relevant clinical data. MVD was 85% in FH, followed by 60% in DLBCL and 43% in low-grade FL. VEGF-A was significantly higher in DLBCL than in low-grade FL and FH. A statistically significant association of MVD and VEGF-A with the International Prognostic Index (IPI) was found in DLBCL. High MVD and VEGF-A expression was observed in DLBCL patients with high IPI, while there was no statistically significant association between MVD and VEGF-A with the Follicular Lymphoma International Prognostic Index in low-grade FL. Our results suggested an important relationship between angiogenesis and high-grade lymphoma.
Keywords
Vascular endothelial growth factor A; Lymphoma, non-Hodgkin; Lymphoma, large B-cell, diffuse; Lymphoma, follicular; Lymph nodes; Hyperplasia
Hrčak ID:
195039
URI
Publication date:
15.12.2017.
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