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Acta Pharmaceutica, Vol. 68 No. 3, 2018.

Short communication, Note

https://doi.org/10.2478/acph-2018-0029

In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations

PLAMEN IVANOV ZAGORCHEV ; Department of Biophysics, Faculty of Pharmacy, Medical University-Plovdiv, 4000 Plovdiv, Bulgaria
ELISAVETA GEORGIEVA APOSTOLOVA orcid id orcid.org/0000-0002-5167-3278 ; Department of Pharmacology and Drug Toxicology, Faculty of Pharmacy, Medical University-Plovdiv, 4000 Plovdiv, Bulgaria
BISSERA ASENOVA PILICHEVA ; Technological center of emergency medicine, 4000 Plovdiv, Bulgaria
MILENA NENKOVA DRAGANOVA-FILIPOVA ; Department of Medical Biology, Medical Faculty, Medical University-Plovdiv, 4000 Plovdiv, Bulgaria; Technological center of emergency medicine, 4000 Plovdiv, Bulgaria
VESELA YULIEVA KOKOVA ; Department of Pharmacology and Drug Toxicology, Faculty of Pharmacy, Medical University-Plovdiv, 4000 Plovdiv, Bulgaria
JULIAN BORISOV LUKANOV ; Department of Biophysics, Faculty of Pharmacy, Medical University-Plovdiv, 4000 Plovdiv, Bulgaria

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Abstract

The aim of this study is to evaluate the antihyperalgesic and antinociceptive effects of two formulations containing peat water extracts using a model of carrageenan-induced hyperalgesia, combined with a test with a mechanical stimulus, and a hot plate test. Rats were divided into seven groups (n = 6) and received local treatment with two peat formulations and two diclofenac formulations dissolved in carbopol gel and Wolff® basis creme, respectively. Carbopol gel, Wolff® basis creme and 0.9 % NaCl without tested substances were used as controls. Both peat formulations exerted an unambiguous antihyperalgesic effect 60 minutes after the treatment. In the hot plate test, the rats treated with the Wolff® basis creme peat formulation showed a tendency to prolonged latency on the first hour. The results could be explained by partial activation of peripheral α2-adrenoceptors and the possible COX-2 suppressive activity.

Keywords

peat; hyperalgesia; Wistar rats

Hrčak ID:

196280

URI

https://hrcak.srce.hr/196280

Publication date:

30.9.2018.

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