Croatica Chemica Acta, Vol. 48 No. 3, 1976.
Short communication, Note
The in vivo Effect of Ultraviolet Irradiation (290-350 nm) on Epidermal Chromatin
A . Kornhauser
; Harvard Scholl of Dental Medicine Boston, Massachusetts 02115
M. A. Pathak
; Department of Dermatology Harvard Medical School Boston, Massachusetts 02115
E. Zimmermann
; University of Munster Physiological Institute 44 Munster, Germany
G. Szabo
; Harvard Scholl of Dental Medicine Boston, Massachusetts 02115
Abstract
In vivo ultraviolet radiation (290-350 nm, 800 J/m2
) in the absence of any exogenously added sensitizer induced oross-ltnkirng of DNA to protein in chromatin isolated from guinea pig epidermis.
The chemical properties and the biologic activity of epidermal
chromatin isolated from both irradiated and non-irradiated
specimens were examined. One hour post-irradiation the lesion was
no more detectable, indicating that a repair process was effective
1n the viable mammalian epidermis.
Keywords
Hrčak ID:
196470
URI
Publication date:
23.9.1976.
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