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https://doi.org/10.3325/cmj.2017.58.424
Severe acrocyanosis precipitated by cold agglutinin secondary to infection with Mycoplasma pneumoniae in a pediatric patient
Bernadett Mosdósi
; Department of Pediatrics, Clinical Center, University of Pecs, Pecs Hungary
Zoltán Nyul
; Department of Pediatrics, Clinical Center, University of Pecs, Pecs Hungary
Arnold Nagy
; Department of Pediatrics, Clinical Center, University of Pecs, Pecs Hungary
Kata Bölcske
; Department of Pharmacology and Pharmacotherapy, Medical School and János Szentágothai Research Center, University of Pécs, Pécs, Hungary
Tamás Decsi
; Department of Pediatrics, Clinical Center, University of Pecs, Pecs Hungary
Zsuzsanna Helyes
; Department of Pharmacology and Pharmacotherapy, Medical School and János Szentágothai Research Center, University of Pécs, Pécs, Hungary
Abstract
This is the first report describing a severe form of cold agglutinin-
induced acrocyanosis with cutaneous necrosis after
Mycoplasma infection in a 9-year-old patient without
any other severe symptoms and laboratory alterations.
We also present the results of two non-invasive methods
used to determine the viability of tissues, degree of tissue
perfusion impairment, and the responsiveness of the microvasculature.
Laser Doppler flowmetry and laser speckle
contrast imaging, both suitable to measure tissue blood
perfusion non-invasively, have been used in the diagnosis
and follow-up of various peripheral vascular diseases.
In our patient, we demonstrated remarkably reduced microcirculation
before the treatment and a significant perfusion
increase in the acral regions after pentoxifylline
therapy. The investigational techniques were useful tools
to assess and quantify the severity of peripheral perfusion
disturbances and to monitor the efficacy of the treatment
in our patient.
Keywords
Hrčak ID:
200236
URI
Publication date:
28.12.2017.
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