Acta clinica Croatica, Vol. 57. No. 2., 2018.
Original scientific paper
https://doi.org/10.20471/acc.2018.57.02.11
Comparison of Different Diagnostic Guidelines for the Diagnosis of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: Single Centre Experience
Marija Jelušić
orcid.org/0000-0002-1728-4260
; Department of Pediatrics, Zagreb University Hospital Centre; University of Zagreb School of Medicine, Zagreb, Croatia
Matea Kronja
; Department of Pediatrics, Zagreb University Hospital Centre; University of Zagreb School of Medicine, Zagreb, Croatia
Marijan Frković
orcid.org/0000-0002-1520-3375
; Department of Pediatrics, Zagreb University Hospital Centre; University of Zagreb School of Medicine, Zagreb, Croatia
Saša Sršen
orcid.org/0000-0001-6555-2613
; Department of Pediatrics, Zagreb University Hospital Centre; University of Zagreb School of Medicine, Zagreb, Croatia
Sanda Huljev Frković
orcid.org/0000-0003-1513-2965
; Department of Pediatrics, Zagreb University Hospital Centre; University of Zagreb School of Medicine, Zagreb, Croatia
Ksenija Štekić Novački
; Department of Pediatrics, Zagreb University Hospital Centre; University of Zagreb School of Medicine, Zagreb, Croatia
Abstract
Macrophage activation syndrome (MAS) is a potentially fatal complication of systemic juvenile idiopathic arthritis (sJIA), caused by exaggerated but ineff ective immune response. The aim of the study was to compare the capacity of the HLH-2004 guidelines with the capacity of the MAS guidelines from 2005, and with the new set of classifi cation criteria from 2016 in diagnosing MAS complicating sJIA. Th e study included 35 children aged 1-18 diagnosed with sJIA according to ILAR criteria and treated at the Department of Pediatrics, Division of Immunology and Rheumatology, Zagreb University Hospital Centre, in the period from 2009 to 2015. Out of 35 patients diagnosed with sJIA, there were 12 girls and 23 boys, with the mean age at disease onset (±SD) 5.51±3.65 years. Eight patients had fl are of disease. With the guidelines from 2005, MAS was diagnosed in six (17.1%) patients with sJIA. With the new set of classifi cation criteria from 2016, MAS was diagnosed in four (11.4%) patients with sJIA. MAS was not diagnosed with the HLH-2004 guidelines. In our study, four out of six patients had MAS at the onset of sJIA, and in the rest two it occurred during relapse. Two patients with MAS developed full-blown clinical picture while another four had incomplete clinical features with minor laboratory alteration. Due to the use of diff erent diagnostic guidelines, we found diff erence in the prevalence of MAS. It was slightly higher in comparison to available studies, while other researched features, such as clinical characteristics, were similar.
Keywords
Macrophage Activation Syndrome; Arthritis, Juvenile; Child; Croatia; Lymphohistiocytosis, Hemophagocytic
Hrčak ID:
207545
URI
Publication date:
1.6.2018.
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