Original scientific paper

https://doi.org/10.2478/acph-2019-001508

Synthesis and evaluation of some new 1,3,4-oxadiazoles bearing thiophene, thiazole, coumarin, pyridine and pyridazine derivatives as antiviral agents

MOHAMMED ALBRATTY ; Department of Pharmaceutical Chemistry, College of Pharmacy Jazan University, P.O. Box 114, Jazan 45142, Saudi Arabia
KARAM AHMED EL-SHARKAWY orcid.org/0000-0003-4421-6113 ; Department of Pharmaceutical Chemistry, College of Pharmacy Jazan University, P.O. Box 114, Jazan 45142, Saudi Arabia; Department of Organic Chemistry, Faculty of Biotechnology October University for Modern Sciences and Arts(MSA) El-Wahat Road, 6 October
HASSAN AHMED ALHAZMI ; Department of Pharmaceutical Chemistry, College of Pharmacy Jazan University, P.O. Box 114, Jazan 45142, Saudi Arabia

Abstract

In an attempt to produce heterocyclic compounds based on 1,3,4-oxadiazole derivatives with potential antiviral activity, the synthesis of compound 1 [2-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)acetonitrile] was performed through the reaction of cyanoacetic acid hydrazide with carbon disulfide in alcoholic potassium hydroxide. Compound 1 has an activating methylene group, so it was directed toward some specific reactions. Thus, aryldiazonium chlorides reacted with compound 1 affording hydrazono derivatives 2a,b,c. Also, aromatic aldehydes reacted with compound 1 to produce compounds 3a,b. Furthermore, cyclic ketones were subjected to synthesis of fused thiophene derivatives 4a,b via the reaction with compound 1 in the presence of elemental sulfur. In addition, 1,3,4-oxadiazole derivative 1 when reacted with isothiocyanates, salicylaldehyde or 1,3-dicarbonyl compounds formed thiazole derivatives 5a,b, coumarin derivative 6 and alkenyl derivatives 7a,b resp. Compound 7b underwent cyclization to afford pyridine derivative 8. Arylhydrazono derivatives 9a,b were produced through the reaction of compound 7a with aryldiazonium chlorides. The latter products 9a,b underwent cyclization to produce pyridazine derivatives 10a,b. Finally 1,3,4-oxadiazole derivative 1 was directed toward the reaction with hydrazine derivatives, bromoacetophenone and ethylchloroacetate affording compounds 11a,b, 12 and 13, resp. The fused thiophene derivatives 14a,b were produced via the reaction of compounds 4a,b with a mixture of malononitrile and ethylorthoformate. Antiviral activity of the synthesized products showed that 5-(4-amino-3-ethyl-2-thioxo-2,3-dihydrothiazol-5-yl)-1,3,4-oxadiazole-2(3H)-thione (5a) and 5-(4-amino-3-phenyl-2-thioxo-2,3-dihydrothiazol-5-yl)-1,3,4-oxadiazole-2(3H)-thione (5b) act as the most active agents against Feline herpes virus, Feline corona virus, Herpes simplex virus-1 and Herpes simplex virus-2, whereas compound 2-(5-(2-phenyl- hydrazono)-4,5-dihydro-1,3,4-oxadiazol-2-yl)acetonitrile (11b) was the most effective against Vaccinia virus, Herpes simplex virus (TK-KOS-ACVr ), Coxsackie virus B4 and Vesicular stomatitis virus.

Keywords

1,3,4-oxadiazole derivatives; thiophene; coumarin; thiazole; pyridine; pyridazine; antiviral activity

Hrčak ID:

207768

URI

https://hrcak.srce.hr/207768

Publication date:

30.6.2019.

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