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https://doi.org/10.20471/acc.2018.57.s1.13

Paneth Cell-Like Component in Prostate Cancer - Case Report

Bernardica Jurić ; Ljudevit Jurak Department of Pathology and Cytology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Šoip Šoipi ; Department of Urology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Monika Ulamec orcid.org/0000-0002-4843-8154 ; Ljudevit Jurak Department of Pathology and Cytology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Department of Pathology, School of Medicine, University of Zagreb, Zagreb, Croatia
Božo Krušlin orcid.org/0000-0002-0480-1687 ; Ljudevit Jurak Department of Pathology and Cytology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Department of Pathology, School of Medicine, University of Zagreb, Zagreb, Croatia

Abstract

Prostate adenocarcinoma with Paneth cell-like neuroendocrine differentiation is a rare entity. Foci of scattered cells and small clusters are found in the majority of described cases, although cases with predominant Paneth cell-like features have also been recorded. These cells contain eosinophilic cyto-plasmic inclusions and lack androgen receptors, and are consequently immune to hormone therapy. It is, therefore, important for pathologists to recognize them. According to literature, clinical outcome depends on the standard grading of the conventional prostate cancer component. We report a case of a 54 year-old patient with prostatic adenocarcinoma showing Paneth cell-like neuroendocrine differentiation.

Keywords

Prostate; Adenocarcinoma; Paneth cells

Hrčak ID:

207905

URI

https://hrcak.srce.hr/207905

Publication date:

1.10.2018.

Article data in other languages: croatian

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