Short communication, Note

Zwitterion Structure in Some 1-Carboxymethylimidazoles and Their Analgetic Activity

V. Šunjić ; »KRKA«, Pharmaceutical and Chemical Works, Instit·ute for Antibiotics, Pharmacy and Technology, Novo Mesto, Slovenia, Yugoslavia
F. Kajfež ; »KRKA«, Pharmaceutical and Chemical Works, Instit·ute for Antibiotics, Pharmacy and Technology, Novo Mesto, Slovenia, Yugoslavia
P. Mildner ; »KRKA«, Pharmaceutical and Chemical Works, Instit·ute for Antibiotics, Pharmacy and Technology, Novo Mesto, Slovenia, Yugoslavia

Abstract

The ratio (R) of zwitterions to neutral molecule was determined
for the derivatives of 1-carboxymethylimidazole. 1-Carboxymethylimidazole (I) and its 2-methyl derivate (III) were found
to be entirely in the form of zwitterion. Of the two 1-carboxymethyl-
2-methyl-nitroimidazoles (V and VII) the 4-nitroisomer (V)
possesses no zwitterionic structure, but the 5-nitroisomer (VII) was
found to be about 65Q/o in the zwitterionic form. The results obtained
are discussed in view of the significant analgetic and sedative
effect observed with tlie compounds having a zwitterionic structure.

Keywords

Hrčak ID:

207962

URI

https://hrcak.srce.hr/207962

Publication date:

1.8.1969.

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