Original scientific paper

Synthesis and Resolution of 1-Phenyl-I-o-chlorophenyl- 3-dimethylamino-propanol-(I)

A. Markovac-Prpić ; Research Department »Pliva « Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia
D . Fleš ; Research Department »Pliva « Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia
M. Milohnoja ; Research Department »Pliva « Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia

Abstract

Racemic 1-pheny 1-1-o:-chloropheny 1-3-dimethy lamino-propanol-(
1) was obtained from 1-o-chlorophenyl-3-dimethylamino-propanone-(
1) hydrochloride via Grignard reaction. The corresponding
(+) and (-)-amino alcohols were obtained by fractional crystallization
of the diastereoisomeric tartrates.

Keywords

Hrčak ID:

208595

URI

https://hrcak.srce.hr/208595

Publication date:

18.5.1961.

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