Croatica Chemica Acta, Vol. 91 No. 3, 2018.
Original scientific paper
https://doi.org/10.5562/cca3353
Synthesis and Antimicrobial Evaluation of Novel Carbazole Based β-diketones and its Pyrazole Derivatives
Vijay A. Kadnor
; Department of Chemistry, A. C. S. College Satral, Rahuri, Ahmednagar, MS 413711, India
Ganesh R. Mhaske
; Department of Chemistry, S. S. G. M. College Kopargaon, Ahmednagar, MS 423601, India
Sharad N. Shelke
; Department of Chemistry, S. S. G. M. College Kopargaon, Ahmednagar, MS 423601, India
Abstract
Novel 9-ethyl-9H-carbazole-3-carboxylic acid derivatives including ester, β-diketone and pyrazole were prepared and characterized by FT-IR, 1H NMR, 13C NMR and mass spectroscopic techniques. All synthesized compounds evaluated for their in vitro antimicrobial activities against four bacteria (Escherichia coli, Pseudomonas putide, Bacillus subtilis, and Streptococcus lactis) and three fungi (Aspergillus niger, Penicillium sp and Candida albicans). Among the compounds tested, 3a, 3b, 3c, 4a, 4b, 4c, 5a and 5b exhibited pronounced antibacterial activity as compared with standard drug ampicillin. Notably, carbazole based pyrazole derivatives 5a and 5b showed potent antifungal activity against C. albicans comparable to reference drug greseofulvin.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Keywords
antimicrobial activity; carbazole; β-diketone; pyrazole
Hrčak ID:
209167
URI
Publication date:
29.12.2018.
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