Biochemia Medica, Vol. 29 No. 1, 2019.
Review article
https://doi.org/10.11613/BM.2019.010501
A review of urinary angiotensin converting enzyme 2 in diabetes and diabetic nephropathy
Akankwasa Gilbert
; Department of laboratory medicine, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of China
Jianhua Liu
; Department of laboratory medicine, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of China
Guixue Cheng
; Department of laboratory medicine, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of China
Changjuan An
; Department of laboratory medicine, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of China
Kabuye Deo
; Department of laboratory medicine, First Teaching Hospital of China Medical University, Shenyang, People’s Republic of China
Abalinda Mary Gorret
; Department of medical laboratory science, Mbarara University of Science and Technology, Mbarara, Uganda
Xiaosong Qin
; Department of laboratory medicine, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of China
Abstract
Urinary angiotensin converting enzyme 2 (ACE2) is significantly increased in diabetes and diabetic nephropathy. While studies on its clinical significance
are still underway, its urinary expression, association with metabolic and renal parameters has been in the recent past considerably studied.
The recent studies have demystified urine ACE2 in many ways and suggested the roles it could play in the management of diabetic nephropathy. In
all studies the expression of urinary ACE2 was determined by enzyme activity assay and/with the quantification of ACE2 protein and mRNA by methods
whose reliability are yet to be evaluated. This review summarizes recent findings on expression of urinary ACE2, examines its relationship with
clinical parameters and highlights possible applications in management of diabetic nephropathy.
Keywords
angiotensin converting enzyme; diabetic nephropathy; mRNA
Hrčak ID:
213854
URI
Publication date:
15.2.2019.
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