Original scientific paper

https://doi.org/10.11613/BM.2019.010705

Higher serum lectin-like oxidized low-density lipoprotein receptor-1 in patients with stable coronary artery disease is associated with major adverse cardiovascular events: A multicentre pilot study

Zi-wen Zhao ; Department of Cardiology, Union Hospital, Fujian Medical University, Fuzhou, P. R. China; Fujian Institute of Coronary Artery Disease, Fuzhou, P. R. China
Yi-wei Xu ; Department of Cardiology, Union Hospital, Fujian Medical University, Fuzhou, P. R. China; Fujian Institute of Coronary Artery Disease, Fuzhou, P. R. China
Shu-mei Li ; Department of Cardiology, The 476 Clinical Department of Fuzhou General Hospital, Fuzhou, P. R. China
Jin-jian Guo ; Department of Cardiology, The Second People’s Hospital of Fujian Province, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. China
Tao Yi ; Department of Cardiology, Union Hospital, Fujian Medical University, Fuzhou, P. R. China; Fujian Institute of Coronary Artery Disease, Fuzhou, P. R. China
Liang-long Chen ; Department of Cardiology, Union Hospital, Fujian Medical University, Fuzhou, P. R. China; Fujian Institute of Coronary Artery Disease, Fuzhou, P. R. China

Abstract

Introduction: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is involved in the pathophysiology of atherosclerosis and acute coronary syndromes (ACS). Circulating soluble LOX-1 (sLOX-1) has been linked to the risk of coronary artery disease (CAD). Our aim was to test if baseline serum sLOX-1 was associated with major adverse cardiovascular events (MACE) in patients with stable CAD.
Materials and methods: This multicentre pilot study enrolled 833 stable CAD patients. All patients were followed for two years. Serum sLOX-1
concentrations were detected by enzyme-linked immunosorbent assay (ELISA). The association between sLOX-1 concentrations and MACE was assessed by logistic regression, Kaplan-Meier survival curves and Cox proportional hazards analyses. Logistic regression analysis was employed to assess
the predictors of complex lesion.
Results: Multivariate logistic regression analysis revealed that sLOX-1 concentration was an independent predictor of MACE (OR 2.07, 95%CI 1.52 - 2.82; P < 0.001). Kaplan-Meier cumulative survival curves showed that the incidence of MACE in patients with a high sLOX-1 concentration was significantly higher than in patients with an intermediate or low sLOX-1 concentration (P < 0.001). Soluble LOX-1 concentrations were independently
correlated with coronary complex lesions (OR 2.32, 95%CI 1.81 - 2.97; P < 0.001).
Conclusions: Baseline sLOX-1 concentrations were correlated with 2-year MACE in stable CAD patients. Furthermore, patients with high serum
sLOX-1 concentrations had higher cumulative incidence of MACE compared to those with low serum sLOX-1 concentrations.

Keywords

coronary artery disease; sLOX-1; prognosis; major adverse cardiovascular events; biomarker

Hrčak ID:

217217

URI

https://hrcak.srce.hr/217217

Publication date:

15.2.2019.

Visits: 1.305 *