Acta clinica Croatica, Vol. 58. No. 1., 2019.
Original scientific paper
https://doi.org/10.20471/acc.2019.58.01.06
Correlation of Peritumoral Brain Edema with Morphological Characteristics and Ki67 Proliferative Index in Resected Intracranial Meningiomas
Hakija Bečulić
orcid.org/0000-0002-6904-2490
; Department of Neurosurgery, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina
Rasim Skomorac
orcid.org/0000-0002-7085-5720
; Department of Neurosurgery, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina
Aldin Jusić
; Department of Neurosurgery, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina
Fahrudin Alić
; Department of Neurosurgery, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina
Anes Mašović
; Department of Neurosurgery, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina
Eldin Burazerović
orcid.org/0000-0002-4273-3937
; Department of Neurosurgery, Sarajevo University Hospital Centre, Sarajevo, Bosnia and Herzegovina;
Ibrahim Omerhodžić
orcid.org/0000-0001-5143-8801
; Department of Neurosurgery, Sarajevo University Hospital Centre, Sarajevo, Bosnia and Herzegovina;
Mirsad Dorić
; Institute of Pathology, Medical Faculty of Sarajevo, Sarajevo, Bosnia and Herzegovina
Melica Imamović
orcid.org/0000-0003-2044-551X
; Department of Emergency Medicine, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina
Alma Mekić-Abazović
; Department of Oncology and Radiotherapy, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina
Alma Efendić
orcid.org/0000-0002-8834-2034
; Department of Radiology, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina
Dalma Udovčić-Gagula
orcid.org/0000-0003-3047-0962
; Institute of Pathology, Sarajevo University Hospital Centre, Sarajevo, Bosnia and Herzegovina
Abstract
The aim of the study was to analyze correlation between morphological characteristics of intracranial meningiomas and Ki67 labeling index (Ki67 LI), and their influence on peritumoral brain edema (PTBE). There were 41 consecutive patients with intracranial meningiomas surgically
treated at the Department of Neurosurgery, Zenica Cantonal Hospital, Zenica, Bosnia and Herzegovina, during the period from January 2010 to December 2015. We reviewed clinical data including patient age, gender, magnetic resonance imaging (MRI) characteristics of the tumor and peritumoral edema, tumor margins, intraoperative characteristics, histopathologic grade and Ki67 LI. In all cases, follow up MRI was obtained at about three months after resection and PTBE was analyzed.
Our research showed the tumor volume, tumor margins, and intraoperative signs of arachnoidal and pial invasion to be associated with PTBE in intracranial meningiomas. Ki67 LI expression correlated
with PTBE. This study showed the resolution of PTBE to depend on invasive behavior of meningioma and KI67 LI. PTBE, pial/cortical and arachnoidal invasion significantly influence the extent of surgical resection.
Keywords
Meningioma; Meningeal neoplasms; Brain edema; Cell proliferation; Ki-67 antigen
Hrčak ID:
220548
URI
Publication date:
1.3.2019.
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