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Liječnički vjesnik, Vol. 141 No. suppl.1, 2019.

Meeting abstract

Suprahepatic inferior caval vein occlusion induced portal and caval hypertension, aortic hypotension and esophageal bleeding. therapy with pentadecapeptide BPC 157

Tajana Đurašin ; School of Medicine University of Zagreb, Department of Pharmacology
Zoya Jelovečki – Dokić ; School of Medicine University of Zagreb, Department of Pharmacology
Josh Fry ; School of Medicine University of Zagreb, Department of Pharmacology
Helena Žižek ; School of Medicine University of Zagreb, Department of Pharmacology
Pavla Peraić ; School of Medicine University of Zagreb, Department of Pharmacology
Filip Radveski ; School of Medicine University of Zagreb, Department of Pharmacology

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Abstract

Pentadecapeptide BPC 157 is intraduced as therapy in a suprahepatic inferior caval vein (ICV) occlusion 15 min, 24h, 48h after complete ICV ligation. Suprahepatic ICV complications that were counteracted by BPC 157 included esophageal bleeding, severe portal and caval hypertension, and aortal hypotension. Likewise, BPC 157 counteracts the lesions in the whole GI-tract. Medication (BPC 157 (10 μg/kg, 10 ng/kg), or saline (5 ml/kg) (controls)) was applied as an abdominal bath immediately after ICV occlusion. ICV occlusion produced severe esophageal bleeding in all controls, along with microscopy findings. Contrarily, given in ischemic period, BPC 157 counteracts severe esophageal bleeding and maintained grossly intact esophageal mucosa . In rats with ICV occlusion, assessment of portal (PV), caval (ICV) and aortal (AA) pressure showed huge portal hypertension and more caval hypertension, along with mild aortic hypotension (15 min: 68±4 PV, 45±4 ICV, 73±3 AA; 24 h: 56±5 PV, 49±5 ICV, 35±3 AA; 48 h 30±3 PV, 48±5 ICV, 39±3 AA-ligation period). Contrarily, BPC 157 in rats with suprahepatic ICV occlusion markedly counteracted portal and caval hypertension, and arterial hypotension (10 μg/kg bath 15 min: 3±1 PV, 9±1 ICV, 117±5 AA; 24 h: 5±1 PV, 9±1 ICV, 67±5 AA; 48 h: 5±1 PV, 9±1 ICV, 70±6 AA), 10 ng/kg bath produced similar results. BPC 157 therapy successfully counteracts the adverse effects of the suprahepatic ICV occlusion.

Keywords

BPC 157; Hypotension; Hypertension; Esophageal bleeding

Hrčak ID:

222560

URI

https://hrcak.srce.hr/222560

Publication date:

9.4.2019.

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