Review article

Cyclodextrin-based pharmaceutical

Mario Jug orcid.org/0000-0002-7473-9807 ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Mira Bećirević-Laćan

Abstract

Cyclodextrins, cyclic oligosacharides, are useful pharmaceutical excipients, which have attracted widespread attention. The ground for their popularity from a pharmaceutical point of view is in their ability to change undesirable characteristics of the drugs, such as unpleasant taste, low aqueous solubility, chemical instability and improving the drug bioavailability by inclusion complex formation. Due to their biocompatibility, cyclodextrins may be used in formulations indented for different routes of drug application including oral, ocular, nasal and even parenteral route. This article outlines the importance and functionality of cyclodextrin in different dosage forms and indicates the possible directions of future development.

Keywords

ciklodekstrin; inkluzijski kompleks; primjena lijeka; topljivost u vodi; kemijska stabilnost; bioraspoloživost

Hrčak ID:

22473

URI

https://hrcak.srce.hr/22473

Publication date:

21.4.2008.

Article data in other languages: croatian

Visits: 4.421 *