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Chemical and Biochemical Engineering Quarterly, Vol. 33 No. 3, 2019.

Original scientific paper

https://doi.org/10.15255/CABEQ.2019.1663

Bone-Mimicking Injectable Gelatine/Hydroxyapatite Hydrogels

A. Rogina orcid id orcid.org/0000-0003-3967-331X ; Faculty of Chemical Engineering and Technology, University of Zagreb, HR-10001 Zagreb, Marulićev trg 19, p.p.177, Croatia
N. Šandrk ; Faculty of Chemical Engineering and Technology, University of Zagreb, HR-10001 Zagreb, Marulićev trg 19, p.p.177, Croatia
L. Teruel-Biosca ; Centre for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain
M. Antunović ; Faculty of Chemical Engineering and Technology, University of Zagreb, HR-10001 Zagreb, Marulićev trg 19, p.p.177, Croatia
M. Ivanković ; Faculty of Chemical Engineering and Technology, University of Zagreb, HR-10001 Zagreb, Marulićev trg 19, p.p.177, Croatia
G. Gallego Ferrer ; b)Centre for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain; c)Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Mariano Esquillor s/n,

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Abstract

Bioactive synthetic hydrogels have emerged as promising materials because they can provide molecularly tailored biofunctions and adjustable mechanical properties. To mimic the mineralogical and organic components of the natural bone, hydroxyapatite and
a tyramine conjugate of gelatine were combined in this study. The effect of various amounts of in situ synthesized hydroxyapatite in gelatine-tyramine on the morphology and physical properties of injectable hydrogels was investigated. Mineralogical identification
confirmed successful precipitation of in situ formed hydroxyapatite. Better distribution of hydroxyapatite crystal agglomerates within modified gelatine was found at 5 % of hydroxyapatite, which could be responsible for increased storage modulus with respect to pure gelatine hydrogel. Prepared composite hydrogels are non-toxic and support the proliferation of Hek293 cells.

Keywords

gelatine; hydroxyapatite; injectable; hydrogel; rheology; cytotoxicity

Hrčak ID:

225896

URI

https://hrcak.srce.hr/225896

Publication date:

7.10.2019.

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