Meeting abstract

https://doi.org/10.15836/ccar2019.242

Treatment of deep vein thrombosis in elderly patients

Ljljana Banfić ; University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia
Majda Vrkić Kirhmajer ; University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia
Marijan Pašalić ; University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia

Abstract

Background: Prevalence of deep vein thrombosis (DVT) in octogenarians is increasing according to
the demographic trends. ACCP guidelines1 published 2016 dramatically influenced on therapeutic
strategies in favor of NOACs versus VKA in DVT/PE treatment. Non inferior efficacy and greater safety
if treated with NOACs was the privilege for therapy in elderly. Seniors are vulnerable mostly because
of increased risk of bleeding, various comorbidities so they are usually undertreated if VKA was prescribed.
Retrospective analysis from our University Center would reveal DVT treatment changes in
elderly patients in the past 45 months that might be influenced by new guidelines recommendation.
Patients and Methods: Analysis included 97 DVT hospitalized patients aged 83.9±4.34 treated in Department
of Cardiovascular diseases, University of Zagreb School of Medicine, in 45 months period
(2016-2019). Proximal DVT occurred in 78.2%, 70% DVT was provoked (cancer related in 35%, 21.6% trauma,
7.6% surgery related, 9.6% bed rest, 19.5 % were already treated with anticoagulants because of atrial
fibrillation).
Results: For the whole observed period (2016-2019) 18% of patients were initially on admission treated
with NOACs and 38 % were switched to NOACs on hospital discharge for continued therapy. DVT treatment
using non VKA has significantly (p=0.008) positive trend with respect of creatinine clearance
values. Only 8.6% population were prescribed NOACs for the extended therapy for DVT or VTE in year
2016. In 2018 and 2019 53% of octogenarians were treated with NOACs for at least 3 months.
Conclusions: DVT pharmacotherapy in senior population according to observational study revealed
significant changes in the 45 months period according to our Centar data. Long term treatment for
DVT in octogenarians was significantly changed, with the positive trend favoring NOACs versus VKA
(p=0.008).

Keywords

deep vein thrombosis; pharmacotherapy; seniors.

Hrčak ID:

226711

URI

https://hrcak.srce.hr/226711

Publication date:

15.10.2019.

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