Croatica Chemica Acta, Vol. 92 No. 2, 2019.
Original scientific paper
https://doi.org/10.5562/cca3536
Organocatalytic Synthesis of α,α–Diaryl Substituted α–Amino Acid Derivatives by an Interrupted Three-Component Ugi Reaction
Danijel Glavač
; Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička c. 54, HR-10000 Zagreb, Croatia
Ivanka Jerić
; Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička c. 54, HR-10000 Zagreb, Croatia
Matija Gredičak
; Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička c. 54, HR-10000 Zagreb, Croatia
Abstract
An organocatalytic interrupted three-component Ugi reaction for the synthesis of α,α–diaryl α–amino acid derivatives is described. The transformation proceeds with a range of isocyanides and 3-aryl isoindolinone alcohols using Brønsted acid catalysts to afford products in good to excellent yields. Based on the obtained results, a reaction mechanism is proposed and discussed.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Keywords
organocatalytic synthesis; α,α–disubstituted amino acids; Ugi reaction
Hrčak ID:
226909
URI
Publication date:
29.7.2019.
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