Professional paper

Pneumococcal associated haemolytic uremic syndrome following invasive pneumococcal disease in a 2-year-old girl

Srđana Čulić orcid.org/0000-0002-7317-6475 ; Split Clinical Hospital Center, Pediatrics Department, Pediatric Haematology, Oncology and Medicine Genetics Department
Dubravka Kuljiš ; Split Clinic Hospital Center, Pediatrics Department, Pediatric Haematology, Oncology and Medicine Genetics Department
Vida Čulić ; Split Clinic Hospital Center, Pediatrics Department, Pediatric Haematology, Oncology and Medicine Genetics Department

Abstract

The haemolytic uremic syndrome is characterized by microangiopathic haemolytic anaemia, thrombocytopenia and acute renal failure and is the most common in children under the age of 4. The etiology can be associated with some infectious agents like Streptococcus pneumoniae. We review the case of a 2-year-old girl presenting with invasive pneumococcal disease followed by the haemolytic uremic syndrome. The onset of the haemolytic uremic syndrome clinical manifestation was preceded by un upper respiratory tract infection. The physical finding was in extremely bad condition with pallor. She was adinamic, confused, dispnoic, dehydrated with peripheral circulatory failure. Tubular breath sounds with moist rales on both sides of the lung were registered as well as liver and spleen enlargement. Presenting clinical and laboratory data we confirmed that, in our case, following the invasive pneumococcal disease (pleuropneumonia, sepsis and septic shock), Streptococcus pneumoniae was the trigger of HUS. High doses of corticosteroids, fresh frozen plasma, antibiotics, and intravenous immunoglobulins were a successful treatment.

Keywords

Haemolytic uremic syndrome; invasive pneumococcal disease; child

Hrčak ID:

22772

URI

https://hrcak.srce.hr/22772

Publication date:

5.5.2008.

Article data in other languages: croatian

Visits: 3.028 *