Review article

Dental Treatment of the Patient with Porphyria

Berislav Perić
Niko Krakar

Abstract

Porphyria is a group of inherited diseases caused by defective enzymes on the biosynthetic pathway of heme. Depending on the specific enzyme defect different forms of porphyria can be differentiated. The consequence of the enzyme defect is the formation of abnormal amounts of porphyrins or precursors which accumulate in the tissues and are excreted in the urine and faeces. Almost all the clinical signs occur because of the effect of these compounds/products on the nervous system and skin. Numerous drugs, such as local anaesthetics (lidocaine), antibiotics (clindamycin, erythromycin, metronidazole) and others, can be precipitating factors and cause acute attacks. Patients with porphyria can safely be given bupivacaine, amoxycillin, clavulanic acid, acethylsalicilic acid and paracetamol (1, 2).
Thus it is important for the dentist to have certain guidelines with regard to the treatment of patients with acute form of porphyria.

Keywords

Porphyria; Drugs

Hrčak ID:

228

URI

https://hrcak.srce.hr/228

Publication date:

15.12.2005.

Article data in other languages: croatian

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