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https://doi.org/10.11613/BM.2020.011003

The effect of jet-lag on serum concentrations of thyroid stimulating hormone and prolactin: A case report

Merve Sibel Gungoren orcid.org/0000-0002-0203-981X ; Duzen Laboratories Group, Ankara, Turkey
Deniz Ilhan Topcu orcid.org/0000-0002-1219-6368 ; Baskent University Medical Faculty, Biochemistry Department, Ankara, Turkey
Cevdet Zungun ; Duzen Laboratories Group, Ankara, Turkey

Abstract

Introduction: This case report is about the importance of sleeping status for analysis of thyroid hormone stimulating hormone (TSH) and prolactin
(PRL) which arose from discordant results of a patient who was referred for serum TSH and PRL testing within 12-hour period after an intercontinental
flight.
Case description: An adult male patient was admitted to our laboratory for serum TSH and PRL tests and came back questioning the accuracy of
his previous results.
Further investigations: A new analysis with a new sample was offered. His new results were not consistent with his previous results.
What happened: It was revealed that the night before the first sampling, he travelled back to Turkey from The United States of America and came
to testing within 12 hours after the arrival.
Discussion: Sleeping status is one of the factors that can affect laboratory results. Intercontinental flights causing jet-lag can alter the secretions of
TSH and PRL which are predominantly modulated by thyrotropin-releasing hormone (TRH).
Main lesson: Travel history and sleeping status are important factors to be evaluated prior sampling for hormone analysis. Patients must be informed
about the importance of sampling timing.

Keywords

preanalytical phase; case report; jet-lag; thyroid stimulating hormone; prolactin

Hrčak ID:

234154

URI

https://hrcak.srce.hr/234154

Publication date:

15.2.2020.

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