Original scientific paper

https://doi.org/10.24869/psyd.2019.235

ASSOCIATIONS BETWEEN POLYMORPHISMS IN THE SOLUTE CARRIER FAMILY 6 MEMBER 3 AND THE MYELIN BASIC PROTEIN GENE AND POSTTRAUMATIC STRESS DISORDER

Mirnesa Muminovic Umihanic ; Community Health Center Zivinice, Živinice, Bosnia and Herzegovina
Romana Babic ; Department of Psychiatry, University Clinical Center of Mostar, Mostar, Bosnia and Herzegovina
Nermina Kravic ; Department of Psychiatry, University Clinical Center of Tuzla, Tuzla, Bosnia and Herzegovina; School of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina
Esmina Avdibegovic ; Department of Psychiatry, University Clinical Center of Tuzla, Tuzla, Bosnia and Herzegovina; School of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina
Alma Dzubur Kulenovic ; Department of Psychiatric, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Ferid Agani ; Faculty of Medicine, University Hasan Prishtina, Prishtina, Kosovo
Miro Jakovljevic ; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia
Dragan Babic ; Department of Psychiatry, University Clinical Center of Mostar, Mostar, Bosnia and Herzegovina
Abdulah Kucukalic ; Department of Psychiatric, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Sabina Kucukalic ; Department of Psychiatric, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Emina Sabic Dzananovic ; Department of Psychiatric, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Alma Bravo Mehmedbasic ; Department of Psychiatric, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Aferdita Goci Uka ; Department of Psychiatry, University Clinical Center of Kosovo, Prishtina, Kosovo
Shpend Haxhibeqiri ; Institute of Kosovo Forensic Psychiatry, University Clinical Center of Kosovo, Prishtina, Kosovo
Blerina Hoxha ; Faculty of Medicine, University Hasan Prishtina, Prishtina, Kosovo
Valdete Haxhibeqiri ; Department of Medical Biochemistry, University Clinical Center of Kosovo, Prishtina, Kosovo
Branka Aukst Margetic ; Department of Psychiatry, University Hospital Centre Sestre Milosrdnice, Zagreb, Croatia
Nenad Jaksic ; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia
Ana Cima Franc ; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia
Dusko Rudan ; Department of Psychiatry, University Hospital Center Zagreb, Zagreb, Croatia
Marko Pavlović ; Department of Psychiatry, University Clinical Center of Mostar, Mostar, Bosnia and Herzegovina
Elma Feric Bojic ; Department of Genetics and Bioengeneering, International Burch University, Sarajevo, Bosnia and Herzegovina
Damir Marjanovic ; Department of Genetics and Bioengeneering, International Burch University, Sarajevo, Bosnia and Herzegovina
Nada Bozina ; Department of Laboratory Diagnostics, University Hospital Center Zagreb, Zagreb, Croatia
Christiane Ziegler ; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany
Christiane Wolf ; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany
Bodo Warrings ; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany
Katharina Domschke ; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany
Jürgen Deckert ; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany
Osman Sinanovic ; School of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina

Abstract

Background: Previous research showed inconsistent results concerning a possible association between solute carrier family 6 member 3 (SLC6A3) gene polymorphisms and dopamine symptoms of posttraumatic stress disorder (PTSD). Several studies also indicate that the myelin basic protein (MBP) gene is of importance in the etiology of several psychiatric disorders. The aim of this study was to investigate the relation of distinct SLC6A3 and MBP gene polymorphisms with PTSD and whether SLC6A3 and MBP genotypes contribute to PTSD symptom severity.
Subjects and methods: The study included 719 individuals who had experienced war trauma in the South Eastern Europe (SEE). Genotypes of variable number tandem repeat (VNTR) polymorphism within the SLC6A3 gene were assessed in 696 participants, and the single nucleotide polymorphism (SNP) rs12458282 located within the MBP gene region was genotyped in a total of 703 subjects. The Mini International Neuropsychiatric Interview, the Clinical Administrated PTSD Scale (CAPS) and Brief Symptom Inventory (BSI), were used for data collection.
Results: No significant differences concerning the investigated SLC6A3 and MBP polymorphisms was identifiable between PTSD and non PTSD participants. Also we could not detect significant influence of these distinct SLC6A3 and MBP alleles on the severity of PTSD symptoms (CAPS) or BSI scores. However, the results of MBP rs12458282 within the patients with lifetime PTSD may point to a possible correlation of the major allele (T) with elevated CAPS scores.
Conclusions: Our results do not support an association of the analysed SLC6A3 and MBP gene polymorphisms with PTSD in war traumatized individuals. We found that there is a possibility for a correlation of the T allele rs12458282 within the MBP gene with higher CAPS scores in lifetime PTSD patients which would need to be tested in a sample providing more statistical power.

Keywords

posttraumatic stress disorder; SLC6A3 (DAT) gene; MBP gene

Hrčak ID:

235151

URI

https://hrcak.srce.hr/235151

Publication date:

9.7.2019.

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