Original scientific paper
https://doi.org/10.15255/CABEQ.2020.1774
Mixed Oxides as Successful Sorption Materials for Some Active Pharmaceutical Ingredients
E. Vrbková
orcid.org/0000-0003-1473-6425
; University of Chemistry and Technology Prague, Technická 5, 16628 Prague, Czech Republic
E. Vyskočilová
; University of Chemistry and Technology Prague, Technická 5, 16628 Prague, Czech Republic
A. Semrádová
; University of Chemistry and Technology Prague, Technická 5, 16628 Prague, Czech Republic
L. Sekerová
orcid.org/0000-0003-0159-5758
; University of Chemistry and Technology Prague, Technická 5, 16628 Prague, Czech Republic
L. Červený
; University of Chemistry and Technology Prague, Technická 5, 16628 Prague, Czech Republic
Abstract
Mixed oxides based on Mg-Al, Mg-Fe, Zn-Al, and Ni-Mg-Al were prepared, characterized and used as sorption materials for different types of active pharmaceutical ingredients (APIs)– nicotinic acid, salicylic acid, ibuprofen, paracetamol and ascorbic acid. Immobilization of APIs on solid supports was confirmed using X-Ray diffraction and
infrared spectroscopy. Overall, the best sorption material for mentioned substances showed to be mixed Mg-Al oxides (>80 % of immobilized substance after 4 h except ascorbic acid). On the other hand, Mg-Fe and Mg-Ni-Al materials did not possess high sorption capacity (max. 59 % after 4 h). From studied substances, the immobilization amount was the lowest in the case of ascorbic acid (max. 44 % immobilized after 4 h),
the highest amount was immobilized in the case of salicylic and nicotinic acids (>95 %, 4 h). The discussion regarding the structure of substances and properties of sorption materials is also offered.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Keywords
API immobilization; sorption; mixed oxides
Hrčak ID:
237049
URI
Publication date:
19.4.2020.
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