Veterinarska stanica, Vol. 51 No. 4, 2020.
Review article
https://doi.org/10.46419/vs.51.4.2
Canine mammary cancer: clinical implications with specific focus on the HER-2 gene
Alejandro Clavijo-Maldonado
; Grupo de Investigación GEBIOME, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas y Naturales, Universidad de Caldas, Manizales, Colombia, Grupo de Propiedades Ópticas de Materiales, Departamento de Física y Química, Universidad Nacional d
Enio Ferreira
; Instituto de Ciências Biológicas, Departamento de Patologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil
Carlos Vargas-Hernández
; Grupo de Propiedades Ópticas de Materiales, Departamento de Física y Química, Universidad Nacional de Colombia Sede Manizales, Manizales, Colombia
Fredy A. Rivera-Páez
; Grupo de Investigación GEBIOME, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas y Naturales, Universidad de Caldas, Manizales, Colombia
Abstract
Canine mammary cancer (CMC) is one of the most common neoplasms in intact females in comparison to other species. Several risk factors have been identified, including breed, genetic predisposition, age, reproductive history, hormonal influence, diet, and body condition, in addition to previous lesions to the mammary gland, such as mammary atypical hyperplasia. An understanding of the genetic markers for the disease and a clinical approach are important for establishing a specific therapy that can allow adequate patient survivorship. Overexpression of the HER-2 gene in canines and humans is associated with a poor clinical prognosis, mainly short survivorship, although the clinical relationship is not clear. The incidence of HER-2 in female dogs can range from 29.7% to 38%. However, overexpression of HER-2 is not necessarily associated with malignancy processes of the mammary tissue, although it participates in cellular proliferation. Finally, canines remain one of the most important models for comparative oncology with humans due to the great similarity in the spontaneous presentation and development of cancer, and in the high homology in the amino acid sequence.
Keywords
c-erbB2; diagnostic; malignant mammary tumour; prognosis; risk factors
Hrčak ID:
238040
URI
Publication date:
12.6.2020.
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