Review article
https://doi.org/10.2478/aiht-2020-71-3366
Ferroptosis: regulated cell death
Ivana Čepelak
; University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Medical Biochemistry and Haematology, Zagreb, Croatia
Slavica Dodig
; University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Medical Biochemistry and Haematology, Zagreb, Croatia
Daniela Čepelak Dodig
; Croatian Institute of Public Health, Department of Toxicology, Zagreb, Croatia
Abstract
Ferroptosis is a recently identified form of regulated cell death that differs from other known forms of cell death morphologically, biochemically, and genetically. The main properties of ferroptosis are free redox-active iron and consequent iron-dependent peroxidation of polyunsaturated fatty acids in cell membrane phospholipids, which results in the accumulation of lipid-based reactive oxygen species due to loss of glutathione peroxidase 4 activity. Ferroptosis has increasingly been associated with neurodegenerative diseases, carcinogenesis, stroke, intracerebral haemorrhage, traumatic brain injury, and ischemia-reperfusion injury. It has also shown a significant therapeutic potential in the treatment of cancer and other diseases. This review summarises current knowledge about and the mechanisms that regulate ferroptosis.
Keywords
glutathione peroxidase 4; iron; lipid peroxidation; reactive oxygen species; system XcČepelak
Hrčak ID:
239231
URI
Publication date:
17.6.2020.
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