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Croatian Medical Journal, Vol. 61 No. 2, 2020.

Original scientific paper

https://doi.org/10.3325/cmj.2020.61.126

Mitochondrial unfolded protein response, mitophagy and other mitochondrial quality control mechanisms in heart disease and aged heart

Tomo Svaguša ; Department of Cardiovascular Diseases, University of Zagreb School of Medicine, Clinical Hospital Dubrava, Zagreb, Croatia
Mislav Martinić orcid id orcid.org/0000-0002-2126-6014 ; University of Zagreb School of Medicine, Zagreb, Croatia
Matea Martinić ; University of Zagreb School of Medicine, Zagreb, Croatia
Lucija Kovačević orcid id orcid.org/0000-0002-2132-9636 ; Department of Diagnostic and Interventional Radiology, University Hospital Center Zagreb, Zagreb, Croatia
Ana Šepac ; Department of Pathology, University of Zagreb School of Medicine, Zagreb, Croatia
Davor Miličić ; Department of Cardiovascular Diseases, University of Zagreb School of Medicine, University Hospital Center Zagreb, Zagreb, Croatia
Joško Bulum ; Department of Cardiovascular Diseases, University of Zagreb School of Medicine, University Hospital Center Zagreb, Zagreb,Croatia
Boris Starčević ; Department of Cardiovascular Diseases, University of Zagreb School of Medicine, Clinical Hospital Dubrava, Zagreb, Croatia
Maja Sirotković Skerlev ; Department of Pathophysiology, University of Zagreb School of Medicine, Zagreb, Croatia
Fran Seiwerth ; Department for Respiratory Diseases Jordanovac, University of Zagreb School of Medicine University Hospital Centre Zagreb, Zagreb, Croatia
Ana Kulić ; Department of Oncology Division of Pathophysiology andExperimental Oncology, UniversityHospital Center Zagreb, Zagreb,Croatia
Filip Sedlić orcid id orcid.org/0000-0002-3733-5985 ; Department of Pathophysiology, University of Zagreb School of Medicine, Zagreb, Croatia

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Abstract

Mitochondria are involved in crucial homeostatic processes in the cell: the production of adenosine triphosphate and reactive oxygen species, and the release of pro-apoptotic molecules. Thus, cell survival depends on the maintenance of proper mitochondrial function by mitochondrial quality control. The most important mitochondrial quality control mechanisms are mitochondrial unfolded protein response, mitophagy, biogenesis, and fusion-fission dynamics. This review deals with mitochondrial quality control in heart diseases, especially myocardial infarction and heart failure. Some previous studies have demonstrated that the activation of mitochondrial quality control mechanisms may be beneficial for the heart, while others have shown that it may lead to heart damage. Our aim was to describe the mechanisms by which mitochondrial quality control contributes to heart protection or damage and to provide evidence that may resolve the seemingly contradictory results from the previous studies.

Keywords

Hrčak ID:

240164

URI

https://hrcak.srce.hr/240164

Publication date:

15.4.2020.

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