Psychiatria Danubina, Vol. 32 No. 2, 2020.
Original scientific paper
https://doi.org/10.24869/psyd.2020.176
RELATIONSHIP BETWEEN BODY MASS INDEX AND EXTRAPYRAMIDAL SYMPTOMS IN ASIAN PATIENTS WITH SCHIZOPHRENIA: THE RESEARCH ON ASIAN PSYCHOTROPIC PRESCRIPTION PATTERNS FOR ANTIPSYCHOTICS (REAP-AP)
Seon-Cheol Park
orcid.org/0000-0003-3691-4624
; Department of Psychiatry, Inje University Haeundae Paik Hospital, Busan, Republic of Korea
Adarsh Tripathi
; Department of Psychiatry, King George’s Medical University, Chowk, Lucknow, India
Ajit Avasthi
; Department of Psychiatry, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
Sandeep Grover
; Department of Psychiatry, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
Andi J. Tanra
; Department of Psychiatry, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Takahiro A. Kato
; Department of Neuropsychiatry, Graduate School of Medicine, Kyushu University, Fukuoka, Japan
Toshiya Inada
; Department of Psychiatry and Psychobiology, Nagoya University, Graduate School of Medicine, Nagoya, Japan
Kok Yoon Chee
; Tunku Abdul Rahman Institute of Neuroscience, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia
Mian-Yoon Chong
; Chang Gung Memorial Hospital, Chiayi, and Chang Gung University School of Medicine, Taiwan
Shu-Yu Yang
; Deparment of Pharmacy, Songde Branch, Tapei City Hospital, Tapei, Taiwan
Sih-Ku Lin
; Psychiatric Center, Taipei City Hospital, Taipei, Taiwan
Kang Sim
; West Region, Institute of Mental Health and Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Yu-Tao Xiang
; Faculty of Health Sciences, Unit of Psychiatry, Institute of Translational Medicine, University of Macau, Macau SAR, China
Afzal Javed
; Pakistan Psychiatric Research Centre, Fountain House, Lahore, Pakistan
Norman Sartorius
; Association for the Improvement of Mental Health Programmes, Geneva, Switzerland
Naotaka Shinfuku
; Department of Social Welfare, School of Human Sciences, Seinan Gakuin University, Fukuoka, Japan
Yong Chon Park
; Department of Neuropsychiatry, Hanyang University Guri Hospital, Guri, Republic of Korea
Abstract
Background: Although an inverse relationship between body mass index (BMI) and Parkinson disease (PD) has been repeatedly reported, to our knowledge, the relationship between BMI and antipsychotic-induced extrapyramidal symptoms (EPS) has rarely been studied in patients with schizophrenia. Our study aimed to evaluate the relationship between BMI and EPS in patients with schizophrenia.
Subjects and methods: Using data from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics (REAP-AP) study, we compared the prevalence of EPS in 1448 schizophrenia patients stratified as underweight, normal range, overweight preobese, overweight obese I, overweight obese II, and overweight obese III according to the World Health Organization (WHO) classification system for body weight status, and with underweight, normal range, overweight at risk, overweight obese I, and overweight obese II according to the Asia-Pacific obesity classification.
Results: In the first step of the WHO classification system for body weight status, adjusting for the potential effects of confounding factors, the multinomial logistic regression model revealed that underweight was significantly associated with greater rates of bradykinesia and muscle rigidity, and a lower rate of gait disturbance. In the second step of the Asia-Pacific obesity classification, adjusting for the potential effects of confounding factors, the multinomial logistic regression model revealed that underweight was significantly associated with a higher rate of muscle rigidity.
Conclusion: Findings of the present study consistently revealed that underweight was associated with a greater rate of muscle rigidity in a stepwise pattern among Asian patients with schizophrenia. Although the mechanism underlying the inverse relationship between BMI and muscle rigidity cannot be sufficiently explained, it is speculated that low BMI may contribute to the development of muscle rigidity regardless of antipsychotic "typicality" and dose in patients with schizophrenia.
Keywords
antipsychotics; Asian, body mass index (BMI); extrapyramidal symptoms (EPS); muscle rigidity; schizophrenia
Hrčak ID:
242273
URI
Publication date:
13.8.2020.
Visits: 924 *