Original scientific paper
Transventricular and Transpial Absorption of Cerebrospinal Fluid into Cerebral Microvessels
Marin Bulat
Veljko Lupret
Darko Orešković
Marijan Klarica
Abstract
It is generally accepted that volume of cerebrospinal fluid (CSF) is secreted in brain ventricles and flows to subarachnoid
space to be absorbed into dural venous sinuses or/and into lymphatics via perineural sheats of cranial nerves.
Since 99% of CSF volume is water, in experiments on cats 3H-water was slowly infused into lateral ventricle and found
that it does not flow to subarachnoid space but that it is rapidly absorbed transventricularly into periventricular capillaries.
When 3H-water was infused in cortical subarachnoid space, it was absorbed locally into cerebral capillaries via
pia mater. On the contrary, when macromolecule 3H-inulin is applied in CSF, it is very slowly eliminated in bloodstream,
and, with time, is carried by systolic-diastolic pulsations and mixing of CSF bidirectionally along CSF system. Thus,
CSF volume (water) is absorbed rapidly into adjacent cerebral capillaries while inulin is distributed bidirectionally due
to its long residence time in CSF. Previously, the macromolecules have been used to study CSF volume hydrodynamics
and with this misconception of CSF physiology arose.
Keywords
cerebrospinal fluid; absorption; cerebral microvessels; water absorption
Hrčak ID:
24552
URI
Publication date:
13.5.2008.
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