Review article

https://doi.org/10.20471/acc.2020.59.03.14

Treatment of Germ Cell Testicular Cancer

Ana Koši Kunac orcid.org/0000-0003-4186-7957 ; Zagreb University Hospital Centre, Department of Oncology, Division of Medical Oncology, Unit of Uro-oncology, Referral Center for Treatment of Germ Cell Tumors and Extragonadal Germ Cell Tumors of the Ministry of Health of the Republic of Croatia, Zagreb, Croatia
Milena Gnjidić ; Zagreb University Hospital Centre, Department of Oncology, Division of Medical Oncology, Unit of Uro-oncology, Referral Center for Treatment of Germ Cell Tumors and Extragonadal Germ Cell Tumors of the Ministry of Health of the Republic of Croatia, Zagreb, Croatia
Zrna Antunac Golubić ; Zagreb University Hospital Centre, Department of Oncology, Division of Medical Oncology, Unit of Uro-oncology, Referral Center for Treatment of Germ Cell Tumors and Extragonadal Germ Cell Tumors of the Ministry of Health of the Republic of Croatia, Zagreb, Croatia
Marija Gamulin ; Zagreb University Hospital Centre, Department of Oncology, Division of Medical Oncology, Unit of Uro-oncology, Referral Center for Treatment of Germ Cell Tumors and Extragonadal Germ Cell Tumors of the Ministry of Health of the Republic of Croatia, Zagreb, Croatia

Abstract

Germ-cell testicular cancer (GCTC) is a malignant neoplasm derived from the primordial germ cell. Although it accounts for approximately 1% of all malignancies in men, it is the most common cancer of younger male population, with the highest incidence between ages 15 and 35.
Testicular cancer incidence rate has risen globally over the past several decades, with the average increase in the incidence of testicular cancer in Croatia of 7% per annum from the year 1983 to 2007. Two main groups are seminomas and non-seminomas, each accounting for 50% of cases, and they differ in treatment modalities and response to therapy. Despite increase in the incidence rate, a promising circumstance is that GCTC has become a model of curable cancer. Because of advances in diagnostic procedures, sophisticated radiation techniques and especially the introduction of cisplatin based chemotherapy protocols together with advanced postchemotherapy surgical techniques, curability is expected in about 95% of all patients diagnosed with testicular cancer and over 70% of patients with advanced disease. In this review, we will focus on treatment strategies of primary GCTC.

Keywords

Germ-cell cancer; Seminoma; Non-seminoma; Chemotherapy

Hrčak ID:

247480

URI

https://hrcak.srce.hr/247480

Publication date:

1.9.2020.

Article data in other languages: croatian

Visits: 2.434 *