Original scientific paper

Gastroprotective effect of the crude methanol extract of Terminalia avicennioides in rats

Mohammed Musa Suleiman ; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria
Isife Ogbonna Romanus ; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria
Sadiq Yusuf ; Department of Human Physiology, Faculty of Medicine, Ahmadu Bello University, Zaria, Nigeria

Abstract

The effect of different doses of methanol extract of Terminalia avicennioides (Combretaceae) on acute mucosal damage induced by 0.6 M HCl and on mucus production in the stomach of rats was studied. Animals treated with T. avicennioides at a dose of 350 mg/kg showed a significant (P<0.05) reduction of gastric lesions produced by HCl, while the reduction in gastric damage was highly significant (P<0.01) at doses of 500 and 900 mg/kg when all the experiments were compared with rats treated with normal saline (untreated control). Similarly, the extract of T. avicennioides at 350, 500 and 900 mg/kg produced a significant (P<0.05) increase in mucus production when compared with normal saline (untreated) and cimetidine (treated) control rats. The effect of the extract on both gastric damage and mucus production were shown to dose-dependent. This study has therefore validated the claim that the plant possesses an ulcer healing effect.

Keywords

Terminalia avicennioides; ulcer; gastroprotection; medicinal plant

Hrčak ID:

24777

URI

https://hrcak.srce.hr/24777

Publication date:

20.8.2007.

Article data in other languages: croatian

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