Croatica Chemica Acta, Vol. 27 No. 3, 1955.
Original scientific paper
Synthetic Studies in the Chloramphenicol Series. IV* Synthesis of threo-DL-Chloramphenicol Base from DL-Serine Methyl Ether
D. Fleš
; Research Department, »Pliva « Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia
B. Balenović
; Research Department, »Pliva « Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia
Abstract
A synthesis of threo-DL-chloramphenicol base from a-bromo-B methoxy-propionic acid, an intermediate in the synthesis of DL-serine methyl ether is described. The synthesis is essentially the same as the one previously described for the preparation of threo-DL-chloramphenicol from DL-serine ethyl ether. However, the over-all yield of chloramphenicol base is much higher (6.9%, based on a-bromo-B-methoxy-propionic acid) mainly due to the high yield of a-phthalimido-B-methoxy-propiophenone, which was obtained in a yield of 63.5 %.
Keywords
Hrčak ID:
247919
URI
Publication date:
1.11.1955.
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