Original scientific paper

Synthetic Studies in the Chloramphenicol Series. II * Synthesis of β-Ethoxy-α-Phthalimido-DL-Propiophenone**

D. Fleš ; Research Institute, »Pliva« Pharmaceutical and Chemical Products, Zagreb, Croatia, Yugoslavia
M. Brajdić ; Research Institute, »Pliva« Pharmaceutical and Chemical Products, Zagreb, Croatia, Yugoslavia
N. Štimac ; Research Institute, »Pliva« Pharmaceutical and Chemical Products, Zagreb, Croatia, Yugoslavia

Abstract

When B-ethoxy-a-phthalimido-DL-propionyl chloride [I] was condensed with benzene in the presence of anhydrous aluminum chloride, B-ethoxy-a-phthalimido-DL-propiophenone [II] was obtained in a yield of 2.3%. Melting point 110° (under previous softening at 106°). [I] gave with diphenylcadmium the same ketone, which was isolated in the form of 2,4-dinitrophenylhydrnzone, in a yield of 3.5 %. Melting point 192-195°.

Keywords

Hrčak ID:

249413

URI

https://hrcak.srce.hr/249413

Publication date:

31.10.1954.

Visits: 339 *