Original scientific paper

Pharmacokinetics of enrofl oxacin in inbred and outbred rabbits

Svetlin Tanchev ; Department of Genetics, Breeding and Reproduction, Agricultural Faculty, Trakia University, Bulgaria
Ljubomur Lashev ; Department of Pharmacology, Toxicology and Therapeutics, Faculty of Veterinary Medicine, Trakia University, Bulgaria
Aneliya Haritova ; Department of Pharmacology, Toxicology and Therapeutics, Faculty of Veterinary Medicine, Trakia University, Bulgaria

Abstract

The pharmacokinetics of enrofloxacin (ENR) were investigated after intravenous (i/v) administration in inbred (n = 10) and outbred (n = 10) healthy rabbits. After i/v ENR injection the elimination half-life (t1/2β), total body clearance (ClB) and the area under the concentration vs. time curve (AUC) in inbred rabbits were 1.51 h, 28.35 ± 1.51 ml/kg/min and 3.01 ± 0.16 μg.h/ml, respectively. The value of t1/2β in outbred rabbits was 2.12 h. The value of ClB (21.47 ± 1.16 ml/kg/min) was significantly lower in outbred rabbits. There were no differences in pharmacokinetic parameters between male outbred and inbred rabbits, and only the value of ClB in female outbred rabbits was significantly lower in comparison to inbred animals. The phenotypic diversity, a manifestation of the complex interaction among the genotype and the environmental factors (the ENR treatment), was clearly less manifested in the inbred group than in outbreds.

Keywords

enrofloxacin; pharmacokinetics; inbred; outbred; rabbits

Hrčak ID:

25200

URI

https://hrcak.srce.hr/25200

Publication date:

20.12.2005.

Article data in other languages: croatian

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