Acta Pharmaceutica, Vol. 72 No. 2, 2022.
Review article
https://doi.org/10.2478/acph-2022-0021
Medicinal plants with anti-SARS-CoV activity repurposing for treatment of COVID-19 infection: A systematic review and meta-analysis
OLUWAKEMI EBENEZER
orcid.org/0000-0003-1054-9665
; Faculty of Natural Science, Department of Chemistry, Mangosuthu University of Technology, 511 Mangosuthu Highway, Durban, 4000, South Africa
OLUSOLA BODEDE
orcid.org/0000-0002-7265-1377
; Department of Agriculture and Animal Health, University of South Africa, Florida Campus, Florida, 1710, South Africa
PAUL AWOLADE
; School of Chemistry and Physics, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban, South Africa
MARYAM A. JORDAAN
; Faculty of Natural Science, Department of Chemistry, Mangosuthu University of Technology, 511 Mangosuthu Highway, Durban, 4000, South Africa
ROPO E. OGUNSAKIN
orcid.org/0000-0003-3853-3382
; Discipline of Public Health Medicine, College of Health Sciences, University of KwaZulu Natal, Durban, 4001, South Africa
MICHAEL SHAPI
; Faculty of Natural Science, Department of Chemistry, Mangosuthu University of Technology, 511 Mangosuthu Highway, Durban, 4000, South Africa
Abstract
The novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus) has emerged as a significant threat to public health with startling drawbacks in all sectors globally. This study investigates the practicality of some medicinal plants for SARS-CoV-2 therapy using a systematic review and meta-analysis of their reported SARS-CoV-1 inhibitory potencies. Relevant data were systematically gathered from three databases, viz., Web of Science, PubMed and Scopus. The information obtained included botanical information, extraction method and extracts concentrations, as well as the proposed mechanisms. Fourteen articles describing 30 different plants met our eligibility criteria. Random effects model and subgroup analysis were applied to investigate heterogeneity. According to subgroup analysis, the substantial heterogeneity of the estimated mean based on the IC50 values reporting the most potent anti-SARS-CoV 3C-like protease (3CLpro) inhibitors (10.07 %, p < 0.0001), was significantly higher compared to the most active anti-SARS-CoV papain-like protease (PLpro) inhibitors (6.12 %, p < 0.0001). More importantly, the literature analysis revealed that fruit extracts of Rheum palmatum Linn. and the compound cryptotanshinone isolated from the root of Salvia miltiorrhiza (IC50 = of 0.8 ± 0.2 µmol L–1) were excellent candidates for anti-SARS-CoV targeting PLpro. Meanwhile, iguesterin (IC50 = 2.6 ± 0.6 µmol L–1) isolated from the bark of Tripterygium regelii emerged as the most excellent candidate for anti-SARS-CoV targeting 3CLpro. The present systematic review and meta-analysis provide valuable and comprehensive information about potential medicinal plants for SARS-CoV-2 inhibition. The chemotypes identified herein can be adopted as a starting point for developing new drugs to contain the novel virus.
Keywords
COVID-19 main protease; inhibition; medicinal plants; systematic review; meta-analysis
Hrčak ID:
262296
URI
Publication date:
30.6.2022.
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