Conference paper

NATURAL KILLER CELL CYTOTOXITY AND COURSE OF ILLNESS IN DEPRESSED MOOD

Christine Reynaert ; Université catholique de Louvain, Cliniques universitaires de Mont-Godinne, Yvoir, Belgium
Pascal Janne ; Université catholique de Louvain, Cliniques universitaires de Mont-Godinne, Yvoir, Belgium
Denis Jacques ; Université catholique de Louvain, Cliniques universitaires de Mont-Godinne, Yvoir, Belgium
David Tordeurs ; Université catholique de Louvain, Cliniques universitaires de Mont-Godinne, Yvoir, Belgium
Nicolas Zdanowicz ; Université catholique de Louvain, Cliniques universitaires de Mont-Godinne, Yvoir, Belgium

Abstract

There is now some evidence that depressed mood is associated with activation of the immune system. First, we evaluated, within
a cross-sectional design, NKCA (in vitro) in 49 subjects meeting inclusion criteria either for a major depressive episode, for
dysthymia, or for “double depression”. We found that recent and long depressive episodes (dysthymia) are associated with a lower
immunodepression. Second, we compared two subset of subjects: 14 patients meeting criteria of major depression to 14 healthy
controls. The data show a significant improvement in major depression when compared to controls througout a treatment combining
supportive psychotherapy and 8 mg Reboxetine™.

Keywords

depression; killer cells; immune system; natural killer cell Activity; reboxetine

Hrčak ID:

262758

URI

https://hrcak.srce.hr/262758

Publication date:

14.9.2010.

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