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Psychiatria Danubina, Vol. 31 No. suppl 2, 2019.

Conference paper

ANHEDONIA IN SCHIZOPHRENIA: MINI-REVIEW

Marina Šagud ; School of Medicine, University of Zagreb, Zagreb, Croatia ;University Hospital Centre Zagreb, Zagreb, Croatia
Ivona Šimunović Filipčić ; University Hospital Centre Zagreb, Zagreb, Croatia
Nenad Jakšić Jakšić ; University Hospital Centre Zagreb, Zagreb, Croatia
Lucija Šimunić Šimunić ; School of Medicine, University of Zagreb, Zagreb, Croatia
Dejana Jezernik ; School of Medicine, University of Zagreb, Zagreb, Croatia
Lucija Tudor ; Laboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia
Zoran Madžarac ; School of Medicine, University of Zagreb, Zagreb, Croatia
Ivana Stefanović ; General Hospital “Dr. Josip Benčević“, Slavonski Brod, Croatia
Biljana Kosanović Rajačić ; School of Medicine, University of Zagreb, Zagreb, Croatia
Alma Mihaljević Peleš ; School of Medicine, University of Zagreb, Zagreb, Croatia ;University Hospital Centre Zagreb, Zagreb, Croatia
Bjanka Vuksan-Ćusa ; School of Medicine, University of Zagreb, Zagreb, Croatia :University Hospital Centre Zagreb, Zagreb, Croatia
Suzan Kudlek Mikulić ; School of Medicine, University of Zagreb, Zagreb, Croatia
Nela Pivac ; Laboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia

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Abstract

The perception of reward exerts a powerful influence on human behavior. While anhedonia might occur in healthy individuals,
its prevalence and severity are much higher in psychiatric patients, particularly those with depression and schizophrenia. Anhedonia
is a negative symptom, and presumably a trait marker in schizophrenia. Recent research confirmed that anhedonia is a complex
construct, consisting of anticipatory, consummatory, and reward learning components. In general, schizophrenia patients show
anticipation deficits, and a substantial portion of them have physical (PA) and social anhedonia (SA). The relationship between
anhedonia and psychopathology appears bidirectional. While gene-environment interactions affect reward circuity, anhedonia
modulates clinical features, such as suicidality and nicotine consumption. Future clinical research employing longitudinal designs
may shed more light on the dynamics and treatment of anhedonia in schizophrenia

Keywords

anhedonia; schizophrenia; negative symptoms; suicidality

Hrčak ID:

262775

URI

https://hrcak.srce.hr/262775

Publication date:

29.5.2019.

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