Conference paper
EFFICACY OF CENTER FOR INTEGRATIVE PSYCHIATRY MULTIMODAL EARLY INTERVENTION SERVICES IN EARLY-PHASE PSYCHOSIS ON HOSPITAL READMISSION
Natko Gereš
; Psychiatric Hospital “Sveti Ivan”, Zagreb, Croatia
Katarina Matić
; Psychiatric Hospital “Sveti Ivan”, Zagreb, Croatia
Diana Prskalo-Čule
; Psychiatric Hospital “Sveti Ivan”, Zagreb, Croatia
Tihana Zadravec Vrbanc
; Psychiatric Hospital “Sveti Ivan”, Zagreb, Croatia
Vanja Lovretić
; Psychiatric Hospital “Sveti Ivan”, Zagreb, Croatia
Katarina Skopljak
; Psychiatric Hospital “Sveti Ivan”, Zagreb, Croatia
Tin Matoš
; Psychiatric Hospital “Sveti Ivan”, Zagreb, Croatia
Josefina Gerlach
; Psychiatric Hospital “Sveti Ivan”, Zagreb, Croatia
Barbara Koret
; Psychiatric Hospital “Sveti Ivan”, Zagreb, Croatia
Ivona Šimunović Filipčić
; University Hospital Center Zagreb, Zagreb, Croatia
Ena Ivezić
; Psychiatric Hospital “Sveti Ivan”, Zagreb, Croatia ; Faculty of Dental Medicine and Health, “Josip Juraj Strossmayer” University of Osijek, Osijek, Croatia
Žarko Bajić
; Psychiatric Hospital “Sveti Ivan”, Zagreb, Croatia
Igor Filipčić
orcid.org/0000-0002-3283-8786
; Psychiatric Hospital “Sveti Ivan”, Zagreb, Croatia; ;Faculty of Dental Medicine and Health, “Josip Juraj Strossmayer” University of Osijek, Osijek, Croatia ;School of Medicine, University of Zagreb, Zagreb, Croatia
Abstract
Background: Growing body of evidence has opened new opportunities to enhance treatment outcomes during early-phase
psychosis (EPP). The objective of this study was to evaluate the effect of the Centre for integrative psychiatry (CIP) multimodal
Early Intervention Services (EIS) on time to relapse in the patients with early-phase psychosis (EPP) during 12 and 24 month period.
Subject and methods: We performed a retrospective cohort study on the sample of 454 EPP patients (duration of the diagnosed
disorder ≤5 years) admitted to Psychiatric Hospital “Sveti Ivan”, Zagreb Croatia, from January 2, 2015, to December 5, 2018, for
the acute treatment of EPP. The end of follow up was March 5, 2019. The primary outcome was the time to rehospitalization because
of relapse during the 12 months from the hospital discharge. Independent variable was the EIS.
Results: We analyzed 454 EPP patients, 260 in EIS group and 194 in no EIS group. After the adjustment for twenty possible
confounding factors using the Cox proportional hazard regression, patients who received EIS had significantly and clinically
relevantly lower hazard for rehospitalization because of relapse during the first 12 months (HR=0.39; CI95% 0.21-0.61; p<0.001),
and during the first 24 months from the hospital discharge (HR=0.56; CI95% 0.39-0.80; p=0.003; sequential Holm-Bonferroni
corrected pcorr=0.004).
Conclusions: Our study indicated efficacy of the CIP multimodal EIS in patients with EPP demonstrated through the time to the
hospital readmission because of relapse during the 12 and 24 months from the hospital discharge. These results strongly support the
need for implementation of multimodal EIS in all patients with EPP.
Keywords
schizophrenia spectrum disorder; early intervention services; early-phase psychosis; schizophrenia
Hrčak ID:
262779
URI
Publication date:
29.5.2019.
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