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Psychiatria Danubina, Vol. 30 No. suppl. 4, 2018.

Conference paper

SMOKING IN SCHIZOPHRENIA: AN UPDATED REVIEW

Marina Šagud ; School of Medicine, University of Zagreb, Zagreb, Croatia; Department of Psychiatry, University Hospital Centre Zagreb, Zagreb, Croatia
Bjanka Vuksan-Ćusa ; School of Medicine, University of Zagreb, Zagreb, Croatia; Department of Psychiatry, University Hospital Centre Zagreb, Zagreb, Croatia
Nenad Jakšić ; Department of Psychiatry, University Hospital Centre Zagreb, Zagreb, Croatia
Alma Mihaljević-Peleš ; School of Medicine, University of Zagreb, Zagreb, Croatia; Department of Psychiatry, University Hospital Centre Zagreb, Zagreb, Croatia
Martina Rojnić Kuzman ; School of Medicine, University of Zagreb, Zagreb, Croatia; Department of Psychiatry, University Hospital Centre Zagreb, Zagreb, Croatia
Nela Pivac ; Laboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia

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Abstract

Patients with schizophrenia continue to have the highest rate of both smoking and heavy nicotine dependence. The interaction between smoking and schizophrenia is complex. There is evidence of the shared genetic background. Recent preclinical and clinical research has further investigated self-medication hypothesis, given that nicotine might alleviate cortical dysfunction. While prior research indicated some favorable effects of smoking on cognitive performance, particulatly on attention/vigilance, recent studies did not confirm those findings. Lower severity of negative symptoms in smokers was not confirmed across studies. Cigarette smoking decreases clozapine and olanzapine concentrations. There is no consistent evidence of favorable effects of nicotine on symptoms in schizophrenia, but the evidence of detrimental effects of smoking on general health is highly consistent. Smoking cessation should be a priority in patients with schizophrenia.

Keywords

cigarette smoking; nicotine dependence; schizophrenia; negative symptoms; cognitive dysfunction; antipsychotic concentration

Hrčak ID:

262899

URI

https://hrcak.srce.hr/262899

Publication date:

22.7.2018.

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