Original scientific paper

https://doi.org/10.31820/ejap.17.3.2

Adapt to Translate – Adaptive Clinical Trials and Biomedical Innovation

Daria Jadreškić orcid.org/0000-0002-6896-8240 ; University of Klagenfurt

Abstract

The article presents the advantages and limitations of adaptive clinical trials for assessing the effectiveness of medical interventions and specifies the conditions that contributed to their development and implementation in clinical practice. I advance two arguments by discussing different cases of adaptive trials. The normative argument is that responsible adaptation should be taken seriously as a new way of doing clinical research insofar as a valid justification, sufficient understanding, and adequate operational conditions are provided. The second argument is historical. The development of adaptive trials can be related to lessons learned from research in cases of urgency and to the decades-long efforts to end the productivity crisis of pharmaceutical research, which led to the emergence of translational, personalized, and, recently, precision medicine movements.

Keywords

adaptive clinical trials; randomized controlled trials; reliability; urgency; precision medicine; translational medicine; the productivity crisis

Hrčak ID:

265890

URI

https://hrcak.srce.hr/265890

Publication date:

30.9.2021.

Article data in other languages: croatian

Visits: 1.898 *