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Original scientific paper

https://doi.org/10.24869/psyd.2021.334

HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH HAEMOPHILIA AND ITS ASSOCIATION WITH DEPRESSIVE SYMPTOMS: A STUDY IN CROATIA AND SLOVENIA

Martina Bago orcid id orcid.org/0000-0001-7957-2076 ; Reference Centre for Pharmacoepidemiology, Andrija Stampar Teaching Institute of Public Health, Zagreb, Croatia
Ana Butkovic ; Faculty of Humanities and Social Sciences, University of Zagreb, Zagreb, Croatia
Barbara Faganel Kotnik ; Division of Paediatrics, University Medical Centre Ljubljana, Ljubljana, Slovenia ; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Ivana Prga orcid id orcid.org/0000-0001-8197-7152 ; Reference Centre for Pharmacoepidemiology, Andrija Stampar Teaching Institute of Public Health, Zagreb, Croatia
Vesna Bačić Vrca ; Hospital Pharmacy, Clinical Hospital Dubrava, Zagreb, Croatia ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Silva Zupančić Šalek ; Department of Internal Medicine, University Hospital Centre Zagreb, Zagreb, Croatia ; Faculty of Medicine, University of Zagreb, Zagreb, Croatia
Irena Preloznik Zupan ; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia; Division of Internal Medicine, University Medical Center Ljubljana, Ljubljana, Slovenia


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Abstract

Background: There are only a few studies in patients with haemophilia (PWH) that examined both quality of life and depressive
symptoms, with only few studies examining their association. Aim of this study was to examine the association between depressive
symptoms and health-related quality of life (HRQoL) in PWH from Croatia and Slovenia.
Subjects and methods: A total of 112 adult PWH on prophylactic (73%) or on-demand (27%) treatment were included in the
study (median age 46 years, range 18-73 years). Depressive symptoms were assessed with BDI-II, HRQoL with SF-36v2,
demographic and socioeconomic data were collected using a questionnaire, and clinical data were obtained from medical records.
Results: All HRQoL scores were significantly negatively correlated with BDI-II in the -0.42 to -0.70 range (all p<0.05). Sociodemographic
and clinical variables explained 28-51% of HRQoL variance scores. Depressive symptoms explained additional
variance for six HRQoL domain scores, with incremental variance being larger for mental domain scores (ranging between 10-
27%), and for Mental Component Summary score (26%).
Conclusions: This study’s findings support that having depressive symptoms is associated with HRQoL of PWH, more so in the
mental health than in the physical health domains.

Keywords

depression; haemophilia A; haemophilia B; quality of life

Hrčak ID:

266018

URI

https://hrcak.srce.hr/266018

Publication date:

22.11.2021.

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