Original scientific paper

Helicobacter Pylori Infection and Coronary Artery Disease

Aleksandar Včev
Dario Nakić
Anamarija Mrđen
Jure Mirat
Sanja Balen
Alen Ružić
Viktor Peršić
Ivan Soldo
Marko Matijević
Jerko Barbić
Valentina Matijević
Dubravko Božić
Branko Radanović

Abstract

The aim of this investigation was to determine the seroprevalence of H. pylori in patients with coronary artery disease
(CAD). Patients with coronary artery disease (n=90) and control group (n=90) were enrolled into this randomized,
multi-centre study. CAD risk factors analyzed included age, male gender, diabetes mellitus, systemic hypertension, cigarette
smoking, hypercholesterolemia and socioeconomic status. The results of this study showed a higher seroprevalence
of Helicobacter pylori infection in patients with CAD compared to controls (78,8% versus 58,3%, p<0.05). However, Helicobacter
pylori seropositivity was not associated with coronary artery risk factors (smoking, body mass index, diabetes
mellitus, hypertension, total cholesterol and socioeconomic status) either in the whole study population or in the patients
and control subjects analyzed separately (P>0.05). Further study are needed to clarify the precise role of Helicobacter
pylori infection on the development of coronary artery disease.

Keywords

Helicobacter pylori infection; coronary artery disease-CAD

Hrčak ID:

26890

URI

https://hrcak.srce.hr/26890

Publication date:

3.9.2007.

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