Review article

Pharmacogenomics – the key to personalized medicine

Dragan Primorac ; St. Catherine Specialty Hospital, Zabok/ Zagreb, Croatia
Lidija Bach-Rojecky ; University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia
Vid Matišić ; St. Catherine Specialty Hospital, Zabok/ Zagreb, Croatia
Vilim Molnar ; St. Catherine Specialty Hospital, Zabok/ Zagreb, Croatia
Marina Dasović ; University of Zagreb, School of Medicine, Zagreb, Croatia

Abstract

Different rates of drug metabolism and the effect of commonly prescribed drugs are often seen in clinical practice.
Some of these differences can be predicted if the patient’s genetic profile is known by pharmacogenomic analysis,
which done once, provides lifetime benefits. In the United States, adverse drug reactions are the fourth leading cause of
death, costing their healthcare system about $136 billion annually. By implementing pharmacogenomic testing early
in clinical algorithms, debilitating and potentially life-threatening side-effects can be predicted and avoided, which is
particularly important in settings of pain therapy and anesthesia. In St. Catherine Specialty Hospital, this approach
is readily advocated for our patients. Through the use of the RightMed panel, 25 genes coding for enzymes and other
proteins important for drug function, are analyzed, and a pharmacogenomic-driven approach is taken by selecting the
right drug, in the right dose, for the right patient.

Keywords

pharmacogenomics, individualized medicine, personalized medicine, analgesia

Hrčak ID:

270505

URI

https://hrcak.srce.hr/270505

Publication date:

28.3.2021.

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