Original scientific paper

https://doi.org/10.21860/medflum2022_271160

Association between atherogenic index of plasma and left ventricular hypertrophy in patients with chronic heart failure with mid-range ejection fraction

Asparuh Nikolov orcid.org/0000-0003-4289-5124 ; Division of Medicine, Cardiovascular Research Working Group, Institute for Scientific Research, Medical University, Pleven, Bulgaria
Maria Tzekova ; Medical University, Pleven, Bulgaria
Konstantin Kostov ; Medical University, Pleven, Bulgaria
Ana Kostadinovska ; Medical University, Pleven, Bulgaria
Svetla Blazheva orcid.org/0000-0001-6870-941X ; Department of Clinical laboratory, clinical immunology and allergology, Medical University, Pleven, Bulgaria

Abstract

Aim: The aim of the present study was to investigate whether an association between lipid indices- atherogenic index of plasma (AIP), Castelli Risk Index I (CRI-I), Castelli Risk Index II (CRI-II) and triglyceride index (TGL-index) and the development of left ventricular hypertrophy exists in patients with heart failure with mid-range ejection fraction (HFmrEF). Material and methods: The study involved 56 patients with HFmrEF and normal lipid profile, median age 64 (47-84) and 22 healthy subjects, median age 58 (51-69). The patients were divided in two subgroups: subjects with left ventricular hypertrophy (n=32); (HFmrEF+LVH) and subjects without left ventricular hypertrophy (n=24); (HFmrEF-LVH). The lipid profile was measured by laboratory, while lipid indices were calculated, using the established formulas. Results: There was not statistically significant difference between the lipid indices in patients with heart failure with mid-range ejection fraction compared to healthy controls (p>0.05). HFmrEF+LVH patients showed statistically significantly higher values of atherogenic index of plasma than HFrEF-LVH patients: 0.16 (0.05/0.37) vs. 0.04 (0.01/0.11); (KW=5.80; p=0.02). TC/HDL, LDL/HDL and TG/HDL values were not significantly higher in HFmrHEF+LVH than HFmrEF-LVH patients: 4.8 (3.98/5.75) vs. 4.49 (3.58/5.63); 2.91 (2.1/4.0) vs. 2.9 (2.5/4.25) and 1.36 (1.11/2.08) vs. 1.13 (0.9/1.53), respectively (p>0.05). No significant gender differences between lipid indices were found. Atherogenic index of plasma showed correlation with LVH (r=0.45; p=0.01) and interventricular septum thickness (r=0.55; p=0.002). Conclusion: Our findings show an association between atherogenic index of plasma and LVH in patients with HFmrEF with normal lipid profile. Further studies are warranted to confirm whether determination of AIP may be used for monitoring development and progression of left ventricular hypertrophy in heart failure with mid-range ejection fraction.

Keywords

heart failure; hypertrophy, left ventricular; lipids

Hrčak ID:

271160

URI

https://hrcak.srce.hr/271160

Publication date:

1.3.2022.

Article data in other languages: croatian

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